Menu

Compound Found in Red Wine Boosts Immune Cell Function

At low doses, resveratrol enhanced human T-cell activity in vitro, while at high doses it interfered with cell signaling. 

Oct 16, 2017
Catherine Offord

ISTOCK, ALEXPRO9500A compound found in red wine that has been linked to a diverse range of therapeutic properties in lab animals has now been shown to enhance human T-cell function, but only at low doses, according to a study published today (October 17) in Science Signaling. Small amounts of resveratrol made cultured CD4+ T cells more responsive to target antigens, researchers found, while larger amounts triggered defective antigen receptor signaling.

“This pharmacological agent has elicited much interest because of its potential to modulate a diverse array of pathological conditions, and it is associated with anticancer, antiaging, and anti-inflammatory properties,” the authors write in their paper. “The data shown here reveal a complex network of resveratrol-stimulated changes in cell cycle progression and metabolism, altering the potential of T lymphocytes to respond to foreign antigens.”

See “Resveratrol’s Low-Dose Anticancer Effect

A polyphenol found in grapes, resveratrol has been shown to prolong life in worms and fruit flies through the activation of SIRT1, an enzyme involved in T-cell signaling and cytokine production. But even after multiple clinical trials, researchers have failed to conclusively demonstrate an extension of these positive effects to humans.

See “Resveratrol May Not Extend Life

In the current study, researchers at the Institute of Molecular Genetics of Montpellier in France showed that, presented with low doses of resveratrol, the SIRT1 protein was activated in human T cells via the mTOR signaling pathway and led to improved T-cell function in vitro. This effect was reversed when the dose was increased, with cells showing impeded mTOR signaling and reduced SIRT1 stimulation.

“Our data suggest that resveratrol is an agent that, by altering the metabolic fitness of T lymphocytes, enhances their cytokine effector potential,” the authors write. Now, they add, “the potential use of resveratrol as a therapy for the treatment of neurological, cardiovascular, hepatic, and metabolic pathologies . . . necessitates a critical evaluation of its effect on T lymphocytes in vivo.”

September 2018

The Muscle Issue

The dynamic tissue reveals its secrets

Marketplace

Sponsored Product Updates

StemExpress LeukopakâNow Available in Frozen Format

StemExpress LeukopakâNow Available in Frozen Format

StemExpress, a Folsom, California based leading supplier of human biospecimens, announces the release of frozen Peripheral Blood Leukopaks. Leukopaks provide an enriched source of peripheral blood mononuclear cells (PBMCs) with low granulocyte and red blood cells that can be used in a variety of downstream cell-based applications.

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

Vector Laboratories, a leader in the development and manufacture of labeling and detection reagents for biomedical research, introduces VECTASHIELD® Vibrance™ – antifade mounting media that delivers significant improvements to the immunofluorescence workflow.

Enabling Genomics-Guided Precision Medicine

Enabling Genomics-Guided Precision Medicine

Download this eBook from Qiagen to learn more about the promise of precision medicine and how QCITM Interpret can help deliver better care with better knowledge.

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Download this white paper from Bertin Technologies to learn how to extract and analyze lipid samples from various models!