Determining mRNA Survival

Researchers uncover a self-destruct mechanism that determines the lifespan of messenger RNA molecules.

Jef Akst
Jef Akst

Jef Akst is managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.

View full profile.


Learn about our editorial policies.

Dec 23, 2011

WIKIMEDIA COMMONS, TOM ELLENBERGER

Observing single molecules in yeast cells in real time, researchers have discovered that the promoter regions of two genes involved in the cell cycle not only act to encourage transcription; they also initiate a self-destruct timer that controls when the resulting messenger RNA (mRNA) molecules are degraded. The results, published today (December 22) in Cell, provide some of the first clues regarding how cells manage their mRNA levels, and could have implications for controlling cell division in cancer.

“Our findings indicate that genes making proteins whose levels must be carefully controlled contain promoter regions that sentence their mRNA molecules to death even as the mRNA is being born,” senior author Robert Singer of the Gruss Lipper Biophotonics Center and Albert Einstein College of Medicine of Yeshiva University said in a press release. “Their lifespans are determined at the moment of their birth.”

Specifically, the...

Due to SWI5 and CLB2’s involvement in the cell cycle, the results could be relevant for developing anti-cancer therapeutics, Singer said. “Once you gain insight into the mechanisms controlling the cell cycle and cell division, you can propose targeted therapies for regulating the uncontrolled cell division that characterizes cancer.”

Interested in reading more?

Become a Member of

Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?