Menu

Dogs’ Friendly Demeanor Written in Their DNA

Researchers pinpoint the genes that make pooches so dang affable.

Jul 20, 2017
Bob Grant

A socialized wolf briefly greeting an unfamiliar experimenter.IMAGE: MONTY SLOANThe key to dogs’ transformation from wild wolves into faithful canine companions may reside in a handful of genes, according to a new study. The authors of the paper, published yesterday (July 19) in Science Advances, suggest that a couple genes in the same region of a single chromosome might have played a role in the extreme sociability that likely attended the domestication of wolves tens of thousands of years ago.

These genes, GTF2I and GTF2IRD1, also play a role in a human disease, Williams-Beuren syndrome, marked by hyper sociability.

“It is great to see initial genetic evidence supporting the self-domestication hypothesis or ‘survival of the friendliest,’” Duke University evolutionary anthropologist Brian Hare, who was not involved in the study, tells Science News. “This is another piece of the puzzle suggesting that humans did not create dogs intentionally, but instead wolves that were friendliest toward humans were at an evolutionary advantage as our two species began to interact.”

Princeton University evolutionary biologist Bridgett vonHoldt and her coauthors studied the behavior of 16 dogs and eight socialized, captive grey wolves, finding that when faced with a cognitively challenging task, dogs spent more time looking at and interacting with humans in the room than did wolves. This, they say, indicates that the dogs were more social. When they peered into the genomes of those canids, as well as genes from other dog breeds registered with the American Kennel Club, the researchers found variations in GTF2I and GTF2IRD1.

“Our finding of genetic variation in both dogs and wolves provides a possible insight into animal personality, and may even suggest similar genes may have roles in other domestic species (maybe cats even),” vonHoldt tells BBC News.

In addition to resolving a facet of dog domestication and personality, the research is a tantalizing and elusive glance at the genetics of behavior. “We struggle a lot with wanting to know genes that are linked to behavior,” vonHoldt tells The New York Times.

See “Genes Linked to Dogs’ Sociability with People

Previously, researchers had suggested other genes were linked with sociability in dogs, and those genes also play roles in human behavioral disorders, such as autism and schizophrenia.

September 2018

The Muscle Issue

The dynamic tissue reveals its secrets

Marketplace

Sponsored Product Updates

Enabling Genomics-Guided Precision Medicine

Enabling Genomics-Guided Precision Medicine

Download this eBook from Qiagen to learn more about the promise of precision medicine and how QCITM Interpret can help deliver better care with better knowledge.

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Download this white paper from Bertin Technologies to learn how to extract and analyze lipid samples from various models!

Bio-Rad Launches CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin for Process Protein Purification

Bio-Rad Launches CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin for Process Protein Purification

Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a global leader of life science research and clinical diagnostic products, today announced the launch of two new chromatography media for process protein purification: CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin.

Immunophenotypic Analysis of Human Blood Leukocyte Subsets

Immunophenotypic Analysis of Human Blood Leukocyte Subsets

Download this application note from ACEA Biosciences, Inc., to find out how to perform an immunophenotypic analysis of a human blood sample utilizing 13 fluorescent markers using a compact benchtop flow cytometer equipped with 3 lasers!