Metcalf earned a medical degree at the University of Sydney in 1953, and spent 60 years as an investigator at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, where he characterized colony stimulating factors (CSFs), which regulate the production of white blood cells. His work on CSFs led to the widespread clinical use of these growth factors to restore immune function in cancer patients undergoing chemotherapy.
“CSFs are now standard treatment and every year the number of people alive because of Don’s work grows,” wrote WEHI Director Douglas Hilton in a tribute to Metcalf. “There can be no greater legacy for a medical researcher.”
“When he was diagnosed with cancer in August . . . the two things he wanted to do was spend as much time as possible with his wife, Jo, and his daughters, but also to continue to do his research,” Hilton told the Australia’s ABC. “His solution was to have his microscope, which was his valued possession at work, shipped home and it sat on his dining room table . . . he’d be able to sneak in some experiments in the afternoon and then spend the time with his wife, so really that kept going until about a month ago.”
Metcalf’s research has also impacted the fields of blood stem cell transplantation and rheumatoid arthritis treatment. He received several awards during his career, including the Albert Lasker Clinical Medical Research Award in 1993.
He is survived by his wife, four daughters, and six grandchildren.