Feudin? genetics style

A nice linkurl:AP story;http://hosted.ap.org/dynamic/stories/H/HATFIELD_MCCOY_SECRET?SITE=PASTR&SECTION=HOME&TEMPLATE=DEFAULT talks about the hypothesis that much of the fuel for the famed Hatfield-McCoy feud might be attributed to Von Hippel-Lindau disease, a rare genetic disorder that predisposes those affected to highly-vascularized tumors. The reasoning is that adrenal tumors might be responsible for many of the McCoys' notorious tempers. There are some great quotes from actual family memb

Brendan Maher
Apr 8, 2007
A nice linkurl:AP story;http://hosted.ap.org/dynamic/stories/H/HATFIELD_MCCOY_SECRET?SITE=PASTR&SECTION=HOME&TEMPLATE=DEFAULT talks about the hypothesis that much of the fuel for the famed Hatfield-McCoy feud might be attributed to Von Hippel-Lindau disease, a rare genetic disorder that predisposes those affected to highly-vascularized tumors. The reasoning is that adrenal tumors might be responsible for many of the McCoys' notorious tempers. There are some great quotes from actual family members in the article. I always liked reading linkurl:and writing about;http://www.the-scientist.com/article/display/13153/ Von Hippel-Lindau. The VHL tumor suppressor deactivates angiogenesis in an interesting oxygen sensing pathway. Normally VHL signals the degradation of hypoxia inducible factor HIF1alpha. In hypoxic conditions, or in the presence of a deactivating VHL mutation HIF1alpha and other protein players initiate transcription of pro angiogenic genes. A book linkurl:I recently reviewed;http://www.the-scientist.com/2007/4/1/57/2/ for the magazine had another take on the famous Appalachian feud. David Sloan Wilson's linkurl:__Evolution for Everyone__;http://www.amazon.com/Evolution-Everyone-Darwins-Theory-Change/dp/0385340214/ref=pd_bbs_sr_1/102-2283572-0016124?ie=UTF8&s=books&qid=1176135306&sr=1-1 mentions research which reasons that a code of behavior adopted...

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