Menu

Growing Placenta-Generating Cells

Researchers derive trophoblast stem cells from mouse fibroblasts, paving the way for cell therapy for placental dysfunction diseases.

Oct 14, 2015
Jef Akst

High-magnification micrograph of intermediate trophoblast cellsWIKIMEDIA, NEPHRONTransiently expressing three genes in mouse fibroblasts, an international team of researchers has coaxed the cells into trophoblast stem-like cells (TSCs), skipping a pluripotent stage. The derived cells had similar characteristics to blastocyst-derived TSCs—which form most of the developing placenta—and contributed to placental cell lineages in vitro, according to a study published last month (September 24) in Cell Stem Cell.

“Here, we describe a method to generate stable and fully functional TSC-like cells from murine fibroblasts by transient ectopic expression of three TSC key master regulators, Gata3, Eomes, and Tfap2c,” the authors wrote in their paper. “These data suggest that the conversion of fibroblasts into iTSCs represents a very high degree of nuclear reprogramming and refute the hypothesis that complete nuclear reprogramming can be achieved only in cells undergoing conversion to ESC-like cells.”

“The success of this study will grant a real chance for women who suffer from placental dysfunction diseases to have healthy babies,” according to a press release. When the placenta does not develop properly or is damaged, the baby be born prematurely, have a low birth weight, or have other complications that can risk both the child’s and mother’s health. “To date, tools to model or treat these diseases are limited because all attempts to isolate and propagate the human placenta precursor cells . . . in the dish have failed.”

September 2018

The Muscle Issue

The dynamic tissue reveals its secrets

Marketplace

Sponsored Product Updates

StemExpress LeukopakâNow Available in Frozen Format

StemExpress LeukopakâNow Available in Frozen Format

StemExpress, a Folsom, California based leading supplier of human biospecimens, announces the release of frozen Peripheral Blood Leukopaks. Leukopaks provide an enriched source of peripheral blood mononuclear cells (PBMCs) with low granulocyte and red blood cells that can be used in a variety of downstream cell-based applications.

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

Vector Laboratories, a leader in the development and manufacture of labeling and detection reagents for biomedical research, introduces VECTASHIELD® Vibrance™ – antifade mounting media that delivers significant improvements to the immunofluorescence workflow.

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Download this white paper from Bertin Technologies to learn how to extract and analyze lipid samples from various models!

Bio-Rad Launches CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin for Process Protein Purification

Bio-Rad Launches CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin for Process Protein Purification

Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a global leader of life science research and clinical diagnostic products, today announced the launch of two new chromatography media for process protein purification: CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin.