Gut drives bone makeovers

The signals that tell your skeleton to lay down new bone come from an unlikely source -- your gut, according to a study published today (Nov. 26) in Cell. "This study revolutionizes how we think about the skeleton," linkurl:Cliff Rosen,;http://www.mmcri.org/cctr/rosen.html a bone biologist from Maine Medical Center Research Institute who was not involved in the research, told The Scientist. "We, as bone [researchers], thought of the skeleton as functioning independent of everything else," Ros

Jennifer Evans
Nov 25, 2008
The signals that tell your skeleton to lay down new bone come from an unlikely source -- your gut, according to a study published today (Nov. 26) in Cell. "This study revolutionizes how we think about the skeleton," linkurl:Cliff Rosen,;http://www.mmcri.org/cctr/rosen.html a bone biologist from Maine Medical Center Research Institute who was not involved in the research, told The Scientist. "We, as bone [researchers], thought of the skeleton as functioning independent of everything else," Rosen said. This group "asked the question, 'could there be other regulators outside the skeleton that are regulating bone?' and found the answer to be 'yes.'" The skeleton undergoes constant linkurl:remodeling;http://www.the-scientist.com/news/display/53475/ and through the steady process of absorbing and laying down new bone, renews itself roughly every 10 years, Rosen said. That remodeling process is thrown off linkurl:balance;http://www.the-scientist.com/article/display/13675/ in certain bone diseases or simply with age, resulting in low bone mass, or osteoporosis. linkurl:Earlier studies;http://www.ncbi.nlm.nih.gov/pubmed/11719191 in patients...
CellThe Scientist.Cell

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