New findings overturn a major model of where immune memory is stored. Rather than circulating throughout the body, as researchers had thought, memory T-cells actually reside in a comfortable niche in the bone marrow waiting for the next chance to fight infection, according to a linkurl:new article;http://www.cell.com/immunity/abstract/S1074-7613(09)00187-3 published online in __Immunity__ today (May 7th).
"It's very exciting data," said Antonio Lanzaveccia from the Institute for Research in Biomedicine in Switzerland, who was not involved in the research. It would be important to see "what the relationship is between these memory cells and other memory cells that have been described," he added. Andreas Radbruch from the Charité German Rheumatology Center in Berlin and colleagues wanted to take a closer look at T memory cells because in earlier studies they had found that memory B-cells, which produce antibodies, reside in the bone marrow. Immunologists have long believed that memory cells come from...
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