- An update on the effort to characterize the protein-coding genes on male-specific regions of the Y chromosome, including genetic components involved with sex determination and reversal, spermatogenesis and male infertility, prostate cancer, sex-specific effects on the brain and behavior, and graft-versus-host disease.
- A report from the Biology/Disease-driven Human Proteome Project (B/D-HPP), which aims to identify proteins that play pivotal roles in a variety of diseases.
- Recent findings from a Taiwanese group conducting a pilot study on chromosome 4, which is rich in cancer-associated proteins and could prove useful in biomarker or drug target applications. The study identifies 141 proteins on the chromosome that are “cell-secretable/shedable proteins” and an additional 54 that are classified as cancer-associated proteins.
- A preliminary map of the proteome of chromosome 8, which has a very high mutation rate in humans and therefore could play an important role in tumorigenesis.
- The announcement of a new data integration and analysis software system and browser designed specifically for the C-HPP.
The issue contains many more updates on the progress of several groups working under the auspices of the C-HPP, and the group aims to publish such a special issue for every year of the project.