Menu

Immune-Boosting Protein Study Questioned

Science adds an editorial expression of concern to an already-corrected study on a protein reported to spur T-cell proliferation in mice.

Dec 23, 2015
Tracy Vence

Human T cellFLICKR, NIAID

Editors at Science have flagged an already-corrected paper on a protein that reportedly boosts the murine immune system published in a May issue of the journal. “Questions have been raised about the validity of findings,” wrote Marcia McNutt, the journal’s editor in chief, in a December 18 editorial expression of concern. In October, Science posted an erratum on the study, noting that the authors had mixed up Western blots in an oversight “due to large number of similar-looking Westerns that were used to produce the figure panels.” The paper’s findings are now being investigated by Imperial College London, where the study’s lead author—Philip Ashton-Rickardt—is a professor of immunology, Retraction Watch reported this week (December 22).

Following publication of the erratum, “we saw that allegations of misconduct continued to be made on public postings,” McNutt told Retraction Watch. “We felt that it was in the best interests of the readers and of the authors that there be a formal investigation so that these concerns be investigated and either put to rest or confronted by the university and the authors so that the matter could reach some sort of resolution.”

An Imperial College spokesperson told Retraction Watch that the institution “will make public the outcome of the investigation, once it has been concluded.” Ashton-Rickardt has not yet responded to a request for comment from Retraction Watch.

November 2018

Intelligent Science

Wrapping our heads around human smarts

Marketplace

Sponsored Product Updates

Slice® Safety Cutters for Lab Work

Slice® Safety Cutters for Lab Work

Slice cutting tools—which feature our patent-pending safety blades—meet many lab-specific requirements. Our scalpels and craft knives are well suited for delicate work, and our utility knives are good for general use.

The Lab of the Future: Alinity Poised to Reinvent Clinical Diagnostic Testing and Help Improve Healthcare

The Lab of the Future: Alinity Poised to Reinvent Clinical Diagnostic Testing and Help Improve Healthcare

Every minute counts when waiting for accurate diagnostic test results to guide critical care decisions, making today's clinical lab more important than ever. In fact, nearly 70 percent of critical care decisions are driven by a diagnostic test.

LGC announces new, integrated, global portfolio brand, Biosearch Technologies, representing genomic tools for mission critical customer applications

LGC announces new, integrated, global portfolio brand, Biosearch Technologies, representing genomic tools for mission critical customer applications

LGC’s Genomics division announced it is transforming its branding under LGC, Biosearch Technologies, a unified portfolio brand integrating optimised genomic analysis technologies and tools to accelerate scientific outcomes.