Menu

Immunological Differences Between Lab Mice and Wild Mice

Discrepancies in the populations’ immune systems suggest murine models of immunological disorders possess more limitations than scientists had appreciated.

May 5, 2017
Diana Kwon

PIXABAY, ALEXAS_FOTOSDespite being one of the most commonly used animals in biomedical research, laboratory mice may not be make the best models for immunology studies, according to a paper published this week (May 3) in Nature Communications.

Researchers at the University of Bristol and the London School of Hygiene & Tropical Medicine compared the immune systems of 181 wild-caught house mice with 64 laboratory-raised animals (Mus musculus domesticus). Compared to the lab mice, the wild mice had highly active immune systems, and 57 of 62 immunological measures, such as serum protein concentrations and natural killer cell populations, differed between the two groups. Lab mice also displayed more sex-related differences than wild ones.

“These results point to us having to be much more cautious in extrapolating from the lab to the wild, but laboratory mouse models will continue to be hugely important in biological and biomedical research,” coauthor Mark Viney said in a statement.

In 2013, another group of researchers reported that murine models do not accurately mimic the genomic responses observed in human inflammatory disease. However, at the time, scientists not involved in the study told The Scientist that different mouse strains needed to be investigated before drawing conclusions.

See “Do Mice Make Bad Models?”

September 2018

The Muscle Issue

The dynamic tissue reveals its secrets

Marketplace

Sponsored Product Updates

StemExpress LeukopakâNow Available in Frozen Format

StemExpress LeukopakâNow Available in Frozen Format

StemExpress, a Folsom, California based leading supplier of human biospecimens, announces the release of frozen Peripheral Blood Leukopaks. Leukopaks provide an enriched source of peripheral blood mononuclear cells (PBMCs) with low granulocyte and red blood cells that can be used in a variety of downstream cell-based applications.

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

Vector Laboratories, a leader in the development and manufacture of labeling and detection reagents for biomedical research, introduces VECTASHIELD® Vibrance™ – antifade mounting media that delivers significant improvements to the immunofluorescence workflow.

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Download this white paper from Bertin Technologies to learn how to extract and analyze lipid samples from various models!

Bio-Rad Launches CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin for Process Protein Purification

Bio-Rad Launches CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin for Process Protein Purification

Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a global leader of life science research and clinical diagnostic products, today announced the launch of two new chromatography media for process protein purification: CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin.