Lindenmann was a postdoc in the 1950s when he and Isaacs discovered that interferons were responsible for blocking future infections after chicken egg membranes had been exposed to an inactivated form of the virus.
According to The New York Times (NYT), “[a]fter his discovery, Dr. Lindenmann returned to his original institution, the University of Zurich, saying he wanted to leave further study of interferons to others.” Lindenmann sought an answer to a phenomenon in laboratory mice that some were resistant to influenza and others not. “The answer turned out to be interferon again,” according to the NYT.
In 1987, upon the 30th anniversary of the discovery of interferon, the Journal of Interferon published a special issue devoted to Lindenmann. Then editor-in-chief Charles Weismann wrote: “Not many scientists have the satisfaction of laying the foundations for a new field of research, and not only living to see its successful evolution but also contributing significantly, time and again, to its development.”
Lindenmann is survived by two sons and four grandchildren.