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Is HIV progression sex-linked?

A genetic variant on the X chromosome may explain why some HIV-infected women are slower to develop full-blown AIDS than men. Although several human genetic variants have been implicated in the control and spread of HIV within a host, this is the first time that a sex chromosome has been found to harbor a suspect stretch of genome related to the disease.HIV-1 budding from cultured lymphocyte Image: C. Goldsmith, courtesy of the Centers for Disease Control and Prevention "I think it's a fasci

Bob Grant
Bob Grant

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A genetic variant on the X chromosome may explain why some HIV-infected women are slower to develop full-blown AIDS than men. Although several human genetic variants have been implicated in the control and spread of HIV within a host, this is the first time that a sex chromosome has been found to harbor a suspect stretch of genome related to the disease.
HIV-1 budding from cultured lymphocyte

Image: C. Goldsmith, courtesy
of the Centers for Disease
Control and Prevention
"I think it's a fascinating piece of work," linkurl:Sunil Ahuja,;http://class.ysu.edu/~polisci/ahuja/index.html an infectious disease geneticist at the University of Texas Health Science Center in San Antonio, told __The Scientist__. "It allows us to begin to probe some of those rather tantalizing reports that [HIV-infected] women generally do better than men," added Ahuja, who was not involved with the study. German researchers identified a single-nucleotide polymorphism (SNP) located on the X chromosome of...




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