Limbs regrow without pluripotency

The cells responsible for the salamander's famed ability to regenerate amputated limbs aren't pluripotent, as scientists have thought, a linkurl:study published online in Nature;http://www.nature.com/nature/journal/v460/n7251/abs/nature08152.html today reports. That's good news for regenerative medicine: If the mechanism salamander cells use for regrowing body parts doesn't depend on pluripotent stem cells, it may be easier than researchers have assumed to mimic that organism's regenerative stra

Jef Akst
Jef Akst

Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf...

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Jun 30, 2009
The cells responsible for the salamander's famed ability to regenerate amputated limbs aren't pluripotent, as scientists have thought, a linkurl:study published online in Nature;http://www.nature.com/nature/journal/v460/n7251/abs/nature08152.html today reports. That's good news for regenerative medicine: If the mechanism salamander cells use for regrowing body parts doesn't depend on pluripotent stem cells, it may be easier than researchers have assumed to mimic that organism's regenerative strategy in potential therapies.
Regenerated limb with
GFP-labeled Schwann cells

Image: Dunja Knapp and
Elly Tanaka
"This is a very important finding for this field and also for regenerative medicine in general," said regeneration biologist linkurl:Andras Simon;http://ki.se/ki/jsp/polopoly.jsp?d=27086&a=24117&cid=27089&l=en of the Karolinska Institutet in Sweden, who was not involved in the research. "The data very strongly suggest that during regeneration cells don't really shift lineage. I think many people expected more flexibility than what this study shows." Salamanders' regenerative abilities were thought to rely on the dedifferentiation of cells near...
Image: Laura Muzinic





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