More support for transcription trick

After recruiting the appropriate cellular machinery, transcription factors can further regulate gene expression by encouraging that machinery to do its job -- copy the DNA into an RNA transcript. DNA PolymeraseImage: Wikimedia commons, The Protein Data Bank PDBA new study published online today (April 29) in Cell helps drive home just how widespread this second level of gene control is, and implicates a cancer-causing transcription factor as a major player in the process. "This is another piec

Jef Akst
Jef Akst

Jef Akst is managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.

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Apr 28, 2010
After recruiting the appropriate cellular machinery, transcription factors can further regulate gene expression by encouraging that machinery to do its job -- copy the DNA into an RNA transcript.
DNA Polymerase
Image: Wikimedia commons,
The Protein Data Bank PDB
A new study published online today (April 29) in Cell helps drive home just how widespread this second level of gene control is, and implicates a cancer-causing transcription factor as a major player in the process. "This is another piece in the puzzle that demonstrates controlling the elongation phase of transcription" -- the production of messenger RNA as the transcriptional apparatus propagates down the gene -- "is one of the more important control mechanisms," said biochemist linkurl:David Price;http://www.biochem.uiowa.edu/price/index.html of the University of Iowa, who was not involved in the study. "[This] paper is going to help convince the field that this is just the way it is." Scientists once believed that...
P.B. Rahl, et al., "c-Myc regulates transcriptional pause release," Cell:141,1-14,2010.



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