After recruiting the appropriate cellular machinery, transcription factors can further regulate gene expression by encouraging that machinery to do its job -- copy the DNA into an RNA transcript.
A new study published online today (April 29) in Cell helps drive home just how widespread this second level of gene control is, and implicates a cancer-causing transcription factor as a major player in the process. "This is another piece in the puzzle that demonstrates controlling the elongation phase of transcription" -- the production of messenger RNA as the transcriptional apparatus propagates down the gene -- "is one of the more important control mechanisms," said biochemist linkurl:David Price;http://www.biochem.uiowa.edu/price/index.html of the University of Iowa, who was not involved in the study. "[This] paper is going to help convince the field that this is just the way it is." Scientists once believed that...
Image: Wikimedia commons,
The Protein Data Bank PDB
P.B. Rahl, et al., "c-Myc regulates transcriptional pause release," Cell:141,1-14,2010.
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