Menu

More than 18,000 Genomic Records from Cancer Patients Available

The publicly available database found nearly a third of samples included mutations targeted by either approved drugs or therapies in clinical trials. 

Jun 1, 2017
Kerry Grens

FLICKR, ADAM NIEMANGenomic information from more than 18,300 patients treated at any of eight academic medical centers in North America and Europe is available for researchers to study. The American Association for Cancer Research GENIE project (for Genomics Evidence Neoplasia Information Exchange) released the data set in January, and in Cancer Discovery today (June 1), the organizers described characteristics of the data, including the types of tumors the patients had, the mutations present, and possible matches with clinical trials.

“The real power of the way this consortium was assembled is that theories can be made of this data and questions formulated, so for patients with a particular rare mutation, maybe you can now see that there are 200 across this dataset, but then you can also look at what happened to those patients,” GENIE steering committee chairperson Charles Sawyers tells GenomeWeb.

The GENIE project started in 2015. The idea behind it is to make available data for researchers to link genomic data with cancer outcomes. The most common tumor types in the data set are non-small cell lung cancer, colorectal cancer, and melanoma.

According to a press release, 30 percent of the samples indicated clinically actionable mutations—with either approved drugs or experimental therapies in clinical trials. “Prior studies looking at how often tumor genome sequencing identifies a clinically actionable mutation have yielded variable results, leading some to question its clinical utility,” Sawyers says in the release. “The huge number of samples in our study and the high rate of clinical actionability give us confidence that tumor genome sequencing can have an important role in clinical care.”

The collection continues to grow. According to the paper, GENIE could expand to more than 100,000 samples in the next five years.

 

September 2018

The Muscle Issue

The dynamic tissue reveals its secrets

Marketplace

Sponsored Product Updates

StemExpress LeukopakâNow Available in Frozen Format

StemExpress LeukopakâNow Available in Frozen Format

StemExpress, a Folsom, California based leading supplier of human biospecimens, announces the release of frozen Peripheral Blood Leukopaks. Leukopaks provide an enriched source of peripheral blood mononuclear cells (PBMCs) with low granulocyte and red blood cells that can be used in a variety of downstream cell-based applications.

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

Vector Laboratories, a leader in the development and manufacture of labeling and detection reagents for biomedical research, introduces VECTASHIELD® Vibrance™ – antifade mounting media that delivers significant improvements to the immunofluorescence workflow.

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Download this white paper from Bertin Technologies to learn how to extract and analyze lipid samples from various models!

Bio-Rad Launches CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin for Process Protein Purification

Bio-Rad Launches CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin for Process Protein Purification

Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a global leader of life science research and clinical diagnostic products, today announced the launch of two new chromatography media for process protein purification: CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin.