Mother’s Genes Influence Baby’s Bacteria

A breast milk-associated gene mutation impacts the establishment of a newborn’s gut microbiome, a study suggests.

Jenny Rood
Apr 13, 2015


Low levels of the human breast milk sugar that feeds the beneficial gut microbe Bifidobacterium result in slower colonization of a baby’s intestines by the bacterium, according to a study published last week (April 9) in Microbiome.

Bifidobacterium, one of the first varieties of microbes to grow in a newborn’s digestive tract, are thought to help prevent infection by lowering the pH of the gut, creating a hostile environment for pathogens. The bacterium’s preferred food source is a breast milk sugar that is made in part by the product of the FUT2 gene. Twenty percent of women carry a mutation in the gene that lowers levels of the sugar in their milk.

To investigate the impact of the FUT2 gene mutation on a baby’s microbiome, researchers from the University of California, Davis, the University of Modena and Reggio Emilia in Italy, and the University of Illinois at Urbana-Champaign studied the milk of 44 mothers, 12 of whom carried the FUT2 mutation, and fecal samples of their infants. The researchers found that Bifidobacteria were slower to arrive in the guts of babies whose mothers lacked functional FUT2. At six days after birth, only 37.5 percent of the infants whose mothers carried the FUT2 mutation had the bacteria; four months later, half of them did. By contrast, 60 percent of the children of “secretor” mothers—those who had a functional copy of the gene—had the bacteria at six days, rising to 80 percent by four months after birth. The earlier the bacteria were established, the larger their population, and the better the babies were at digesting sugars in the mother’s milk.

The authors cautioned that the small study did not account for environmental effects that could have confounded the results, and that other genes are also important in creating the complicated breast milk mixture. “In no way is the nonsecretor mother’s milk less healthy, and their babies are at no greater risk,” study coauthor David Mills of Davis emphasized in a statement. “What this work does show us is that the mother's genotype matters.”

“It shows that establishing the microbiome is an intricate process, orchestrated by the breast milk,” study coauthor Zachery Lewis of Davis told NPR’s Shots.