New antibodies block HIV
Newly discovered broadly neutralizing antibodies appear to block HIV from entering and infecting human immune cells. These include two antibodies that thwart more than 90 percent of circulating HIV-1 strains, a discovery that may aid in the development of a vaccine. VRC01 (green and blue) binding to the gp120envelope glycoprotein (gray) and theHIV-1 site of vulnerability (red).Image courtesy of Peter Kwong, Jonathan Stuckey,Tongquing ZhouThe researcher team, composed mainly of scientists with t
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Newly discovered broadly neutralizing antibodies appear to block HIV from entering and infecting human immune cells. These include two antibodies that thwart more than 90 percent of circulating HIV-1 strains, a discovery that may aid in the development of a vaccine.
The researcher team, composed mainly of scientists with the National Institutes of Health, reports the linkurl:findings;http://www.sciencemag.org/cgi/content/abstract/science.1187659 and details of a new method used to single out the antibodies from the blood of an HIV-positive patient using a specially designed glycoprotein probe on __Science__'s website today (8th July). The new antibody detection method "is an extraordinary hook that has allowed them to fish out antibodies that are unique and special," linkurl:Munir Alam;http://humanvaccine.duke.edu/modules/alam/index.php?id=1, an immunologist at Duke University's Human Vaccine Institute who was not...
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envelope glycoprotein (gray) and the HIV-1 site of vulnerability (red). Image courtesy of Peter Kwong, Jonathan Stuckey, Tongquing Zhou |
X. Wu, et al., linkurl:"Rational Design of Envelope Surface Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1,";http://www.sciencemag.org/cgi/content/abstract/science.1187659 __Science__, published online 8 July 2010, doi: 10.1126/science.1187659.T. Zhou, et al., linkurl:"Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01,";http://www.sciencemag.org/cgi/content/abstract/science.1192819 __Science__, published online 8 July 2010, doi: 10.1126/science.1192819.
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