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New cell cycle complexities

New findings are calling into question a long-held theory for how a dividing cell decides to stop the process of mitosis and restart the cell cycle. Chromosomes (blue) and mitoticspindle (green) during cell division Image: Oak Ridge Nat'l Lab, via Wikipedia Science textbooks have long claimed that what drives this decision is the breakdown of cell cycle-related proteins called cyclins at the end of the cycle's mitosis phase, but a linkurl:study published online;http://www.nature.com/nature/jou

Alla Katsnelson
New findings are calling into question a long-held theory for how a dividing cell decides to stop the process of mitosis and restart the cell cycle.
Chromosomes (blue) and mitotic
spindle (green) during cell division

Image: Oak Ridge Nat'l Lab, via Wikipedia
Science textbooks have long claimed that what drives this decision is the breakdown of cell cycle-related proteins called cyclins at the end of the cycle's mitosis phase, but a linkurl:study published online;http://www.nature.com/nature/journal/vaop/ncurrent/full/nature07984.html this week in Nature suggests things may not be that simple. Instead, the authors propose cyclin levels regulate a genetic feedback mechanism that makes sure cell cycle stages happen in the right order. Two of the study's authors "have been championing this view for years now, and it's [good] to see the experimental test of this view pan out so nicely," linkurl:James Ferrell,;http://www.stanford.edu/group/ferrelllab/ a molecular and systems biologist at Stanford University who was not involved in...
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