New neurons rewire mouse brain

Embryonic neurons transplanted into mice can induce a period of flexibility in a relatively rigid older brain, suggesting a possible mechanism to repair damaged brain circuits, according a study published this week in Science. Inhibitory neurons transplantedfrom the embryonic braininto the postnatal brain Image: Derek Southwell"It's terrific," said neuroscientist linkurl:Takao Hensch;http://golgi.harvard.edu/Faculty/faculty_profile.php?f=takao-hensch of Harvard University, who was not involved

Jef Akst
Jef Akst

Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf...

View full profile.


Learn about our editorial policies.

Feb 24, 2010
Embryonic neurons transplanted into mice can induce a period of flexibility in a relatively rigid older brain, suggesting a possible mechanism to repair damaged brain circuits, according a study published this week in Science.
Inhibitory neurons transplanted
from the embryonic brain
into the postnatal brain

Image: Derek Southwell
"It's terrific," said neuroscientist linkurl:Takao Hensch;http://golgi.harvard.edu/Faculty/faculty_profile.php?f=takao-hensch of Harvard University, who was not involved in the research. "This is a very nice demonstration that just transplanting those very cells that [influence brain development] initially can reintroduce a period of plasticity. The obvious therapeutic implications are very exciting." As a young brain matures, it goes through various periods of reorganization known as critical periods -- short bursts of neural plasticity. The development of the visual system, for example, involves a period of brain plasticity shortly after birth in which neurons are rewired to "match up the connections in the visual cortex so that...




Interested in reading more?

Become a Member of

Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?