Menu

New Resource for Banked iPSCs

Researchers describe hundreds of induced pluripotent stem cell lines from healthy individuals. 

May 11, 2017
Aggie Mika

WIKIMEDIA, CSIRO

                 An international team of scientists has characterized and made available 711 induced pluripotent stem cell (iPSC) lines from 301 healthy individuals, according to a paper published today (May 10) in Nature. The researchers also investigated sources of variability within these banked cell lines, a common characteristic of existing iPSC lines that can pose challenges for researchers.  

“Many other efforts to create stem cells focus on rare diseases. In our study, stem cells have been produced from hundreds of healthy volunteers to study common genetic variation,” said Fiona Watt, lead author and Director of the Centre for Stem Cells and Regenerative Medicine at King's College London, in a press release

Because the researchers derived more than one cell line from individual participants, they were able to demonstrate that “up to 46 percent of the differences we saw in iPS cells were due to differences between individuals,” Watt said, indicating that genetic differences between people drives variation in the cells’ phenotypes. 

“These data will allow researchers to put disease variations in context with healthy people,” she added.

See “Banking on iPSCs

This endeavor was part of the Human Induced Pluripotent Stem Cell Initiative, which is described by the authors in the study as “a large, high-quality, open-access reference panel of human iPSC lines”

“This resource is a stepping stone for researchers to make better cell models of many diseases, because they can study disease risk in many cell types, including those that are normally inaccessible,” said Daniel Gaffney, a lead author and a geneticist at the Wellcome Trust Sanger Institute. 

April 2019

Will Car T Cells Smash Tumors?

New trials take the therapy beyond the blood

Marketplace

Sponsored Product Updates

Myth Busting: The Best Way to Use Pure Water in the Lab
Myth Busting: The Best Way to Use Pure Water in the Lab
Download this white paper from ELGA LabWater to learn about the role of pure water in the laboratory and the advantages of in-house water purification!
Shimadzu's New Nexera UHPLC Series with AI and IoT Enhancements Sets Industry Standard for Intelligence, Efficiency and Design
Shimadzu's New Nexera UHPLC Series with AI and IoT Enhancements Sets Industry Standard for Intelligence, Efficiency and Design
Shimadzu Corporation announces the release of the Nexera Ultra High-Performance Liquid Chromatograph series, incorporating artificial intelligence as Analytical Intelligence, allowing systems to detect and resolve issues automatically. The Nexera series makes lab management simple by integrating IoT and device networking, enabling users to easily review instrument status, optimize resource allocation, and achieve higher throughput.
IDT lowers genomic barriers with powerful rhAmpSeq™ targeted sequencing system
IDT lowers genomic barriers with powerful rhAmpSeq™ targeted sequencing system
Increasing accuracy and reducing cost barriers, IDT’s innovative system delivers simple and cost-effective amplicon sequencing
Bio-Rad Introduces Isotype-Specific Secondary Antibodies
Bio-Rad Introduces Isotype-Specific Secondary Antibodies
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a global leader of life science research and clinical diagnostic products, today announced the launch of its isotype-specific secondary antibodies. This new range of recombinant monoclonal antibodies, directed against the three main mouse isotypes: IgG1, IgG2a, and IgG2b, offer improved signal detection and specificity in imaging, ELISA, flow cytometry, and western blotting.