For the first time, human skin cells have been reprogrammed without using DNA, according to a linkurl:study;http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(09)00214-8 published online today (May 28) in __Cell Stem Cell__. Although further optimization is still required, this new technique, which involves only four genetically engineered proteins, could yield the first clinic-ready human induced pluripotent stem (iPS) cells.
"This is the first safe method for generating patient-specific stem cells," linkurl:Robert Lanza,;http://www.robertlanza.com/ chief scientific officer of Advanced Cell Technology (ACT), who coauthored the study, told __The Scientist__. "We now have a way to actually go into a patient without the problem of immune rejection." linkurl:Last month,;http://www.the-scientist.com/blog/display/55657/ a team led by the Scripps Research Institute's linkurl:Sheng Ding;http://www.scripps.edu/chem/ding/ reported the first DNA-free method for obtaining iPS cells, although his team only published experiments using mouse cells. Ding and his colleagues started with the four most commonly used...
by direct protein delivery
Image: Kwang-Soo Kim
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