Pig-to-Pig Transmission of Mosquito-Borne Virus

The Japanese encephalitis virus, which typically moves to new hosts via mosquito vectors, can jump directly between pigs, according to a study.

Feb 29, 2016
Jef Akst

FLICKR, UNITED SOYBEAN BOARDPigs can catch the Japanese encephalitis virus, the leading cause of childhood encephalitis in Asia, directly from other pigs, bypassing the mosquito vector once thought to be necessary for viral spread, according to a study published last week (February 23) in Nature Communications. When researchers housed healthy pigs with animals they’d injected with the virus, some of the healthy swine also became infected, and the virus stayed in the pigs’ lymphatic tissue and tonsils for weeks.

It is unclear if this form of sharing the disease also occurs outside of the lab. “It’s probably not the dominant mode of transmission,” Juliet Pulliam, a virologist at the University of Florida in Gainesville who was not involved in the research, told Science. But pig-to-pig transmission could explain how the virus sometimes persists year-round, even in the winter when mosquito populations decline.

“If you look in the older literature, you find a lot of speculation,” study coauthor Artur Summerfield, a virologist at the Institute of Virology and Immunology in Bern, Switzerland, told Science. “But nobody was able to demonstrate where [the virus] was sleeping in the winter.”

This is the first study to demonstrate mosquito-free spread of the Japanese encephalitis virus, but previous research has shown that the closely related West Nile virus can be transmitted directly from bird to bird. And recent reports have suggested that the mosquito-borne Zika virus may be transmitted sexually between humans. “As we’re getting better at looking at things, people are noticing these weird patterns,” Pulliam told Science. “We’re starting to pick up on things that maybe we wouldn’t have picked up on before.”