Piggybacking to pluripotency

Researchers have for the first time reprogrammed human skin cells to a pluripotent state without using viruses, according to twin studies published online today in __Nature__. The approach "is truly epigenetic," linkurl:Richard Young,;http://web.wi.mit.edu/young/ a geneticist at the Whitehead Institute in Cambridge, Mass., who was not involved in the research, told __The Scientist__. "You introduce a set of master regulators, they're expressed, they reprogram the cell, and then you successfully

Elie Dolgin
Feb 28, 2009
Researchers have for the first time reprogrammed human skin cells to a pluripotent state without using viruses, according to twin studies published online today in __Nature__. The approach "is truly epigenetic," linkurl:Richard Young,;http://web.wi.mit.edu/young/ a geneticist at the Whitehead Institute in Cambridge, Mass., who was not involved in the research, told __The Scientist__. "You introduce a set of master regulators, they're expressed, they reprogram the cell, and then you successfully remove them from the cell for all time." "It opens up a gate to increased safety for the future use of the cells in cell-based therapies," said linkurl:Andras Nagy,;http://www.mshri.on.ca/nagy/ a stem cell researcher at the Mount Sinai Hospital in Toronto and one of the study's lead authors.
Human iPS cells

Image: Kyoto University / AP
In the past few years, researchers have used retroviruses, lentiviruses, adenoviruses, and plasmids to insert reprogramming factors into differentiated cells to create induced pluripotent stem (iPS)...




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