Pluripotency not required

In a striking demonstration of cellular flexibility, scientists have created functioning neurons from fibroblasts, without going through an intermediate pluripotent stage, according to a study published online this week in Nature. Mouse cingulate cortex neuronsImage: Wikimedia commons"It's really exciting," said molecular geneticist Mathias Treier of the linkurl:European Molecular Biology Laboratory;http://www.embl.de/index.php and the linkurl:University of Cologne in Germany,;http://www.presso

Jef Akst
Jef Akst

Jef Akst is managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.

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Jan 26, 2010
In a striking demonstration of cellular flexibility, scientists have created functioning neurons from fibroblasts, without going through an intermediate pluripotent stage, according to a study published online this week in Nature.
Mouse cingulate cortex neurons
Image: Wikimedia commons
"It's really exciting," said molecular geneticist Mathias Treier of the linkurl:European Molecular Biology Laboratory;http://www.embl.de/index.php and the linkurl:University of Cologne in Germany,;http://www.pressoffice.uni-koeln.de/ who was not involved in the research. "It shows that cells can switch their fate" without going through the pluripotent state, avoiding the potential for tumor formation. "[In] the future, with the right cocktail mix, this [might be] possible for other tissues and organs," he added. Inspired by Shinya Yamanaka's discovery of four transcription factors that could induce a differentiated cell to regress to a pluripotent state, which could then be redifferentiated into another adult cell type, stem cell biologist linkurl:Marius Wernig;https://med.stanford.edu/profiles/frdActionServlet?choiceId=facProfile&fid=10445 of Stanford University School of Medicine wondered if...
Ascl1, Brn2,Myt1lFoxl2The ScientistThe Scientist



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