Pluripotency not required

In a striking demonstration of cellular flexibility, scientists have created functioning neurons from fibroblasts, without going through an intermediate pluripotent stage, according to a study published online this week in Nature. Mouse cingulate cortex neuronsImage: Wikimedia commons"It's really exciting," said molecular geneticist Mathias Treier of the linkurl:European Molecular Biology Laboratory;http://www.embl.de/index.php and the linkurl:University of Cologne in Germany,;http://www.presso

Jef Akst
Jef Akst

Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf...

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Jan 26, 2010
In a striking demonstration of cellular flexibility, scientists have created functioning neurons from fibroblasts, without going through an intermediate pluripotent stage, according to a study published online this week in Nature.
Mouse cingulate cortex neurons
Image: Wikimedia commons
"It's really exciting," said molecular geneticist Mathias Treier of the linkurl:European Molecular Biology Laboratory;http://www.embl.de/index.php and the linkurl:University of Cologne in Germany,;http://www.pressoffice.uni-koeln.de/ who was not involved in the research. "It shows that cells can switch their fate" without going through the pluripotent state, avoiding the potential for tumor formation. "[In] the future, with the right cocktail mix, this [might be] possible for other tissues and organs," he added. Inspired by Shinya Yamanaka's discovery of four transcription factors that could induce a differentiated cell to regress to a pluripotent state, which could then be redifferentiated into another adult cell type, stem cell biologist linkurl:Marius Wernig;https://med.stanford.edu/profiles/frdActionServlet?choiceId=facProfile&fid=10445 of Stanford University School of Medicine wondered if...
Ascl1, Brn2,Myt1lFoxl2The ScientistThe Scientist



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