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Proteins link diet to longevity

Scientists have elucidated a key element of how diet restriction might boost life span. A single pair of proteins, whose activity is linked to diminished food intake, is responsible for significantly increasing the lifespan of worms, a linkurl:study;http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08130.html published in this week's __Nature__ reports. "[This study] is going to open a field that's probably going to be important for mammalian life," said gerontologist linkurl:Nir Ba

Bob Grant
Bob Grant

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Scientists have elucidated a key element of how diet restriction might boost life span. A single pair of proteins, whose activity is linked to diminished food intake, is responsible for significantly increasing the lifespan of worms, a linkurl:study;http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08130.html published in this week's __Nature__ reports. "[This study] is going to open a field that's probably going to be important for mammalian life," said gerontologist linkurl:Nir Barzilai;http://molgen.aecom.yu.edu/index.php?option=com_content&task=view&id=45&Itemid=68 of the Albert Einstein College of Medicine in New York, who was not involved in the study. He cautioned that since the study was done in worms, its relevance to mammalian aging isn't yet clear. "It's not totally translatable, but it is exciting," he said.
__C. elegans__

Image: NGHRI
Scientists have been studying the phenomenon of increased longevity with diet restriction for about 70 years, and have replicated the effect in many species, from mice and fish to yeast and primates. But until about two...



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