Safety review for obesity drug

The linkurl:US Food and Drug Administration;http://www.google.com/url?sa=t&source=web&ct=res&cd=1&url=http%3A%2F%2Fwww.fda.gov%2F&ei=4_iTSozKI4nKlAeUkPnGAg&usg=AFQjCNEC-Qs0EIMQO8U_uagEsakq0iVJIg&sig2=UIOXgDn12FgqwiQKkj4lXg linkurl:announced yesterday;http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm180057.htm (August 24) that it was reviewing reports of liver injury -- including 6 cases of liver failure and 27 hospitalizations -- in patients taking the weight loss drug orlistat, mark

Jef Akst
Jef Akst

Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf...

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Aug 24, 2009
The linkurl:US Food and Drug Administration;http://www.google.com/url?sa=t&source=web&ct=res&cd=1&url=http%3A%2F%2Fwww.fda.gov%2F&ei=4_iTSozKI4nKlAeUkPnGAg&usg=AFQjCNEC-Qs0EIMQO8U_uagEsakq0iVJIg&sig2=UIOXgDn12FgqwiQKkj4lXg linkurl:announced yesterday;http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm180057.htm (August 24) that it was reviewing reports of liver injury -- including 6 cases of liver failure and 27 hospitalizations -- in patients taking the weight loss drug orlistat, marketed by linkurl:GlaxoSmithKline;http://www.google.com/url?sa=t&source=web&ct=res&cd=1&url=http%3A%2F%2Fwww.gsk.com%2F&ei=EfmTSuWbC4bDlAfQ0dilDA&usg=AFQjCNEulfO2BWlzMRoh1f47VF6FQlEbvA&sig2=GHCIX5IZlaoaNKzMs7S8Sg (GSK) and linkurl:Roche.;http://www.google.com/url?sa=t&source=web&ct=res&cd=1&url=http%3A%2F%2Fwww.roche.com%2F&ei=IfmTSpjCCpWGlAe8u8ypDA&usg=AFQjCNH62u2MN1Zin7KuxHBJmH6OfA6AoA&sig2=N37lvDTNz9wHBt_amOE0jQ
Image: Wikimedia commons
In 2007, GSK's formulation of orlistat, alli -- so named to sound connote an ally in weight loss -- became the first diet drug to be sold over-the-counter (OTC). GSK paid $100 million to purchase the licensing rights to orlistat from Switzerland-based manufacturer Roche, who developed and still markets the prescription version, Xenical. (The Scientist wrote about the deal and the lengthy process of turning orlistat into an OTC drug in a linkurl:feature article;http://www.the-scientist.com/article/display/54717/ last year.) In 2008, its first full year as an OTC diet drug, alli's sales were estimated at $500 million, with future projections of $1 billion annually, according to...




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