Shoring Up Golgi To Slow Alzheimer’s

Blocking activity of a kinase in a mouse model protects Golgi in cells and reduces the build-up of amyloid β, a primary component of Alzheimer’s disease.

kerry grens
Kerry Grens

Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at...

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WIKIMEDIA, KELVINSONGThe Golgi organelle gets dismantled in neurons affected by Alzheimer’s disease (AD). In a study to be presented at the American Society for Cell Biology (ASCB) conference this week, researchers show that protecting Golgi from breaking down can actually stall the accumulation of amyloid β (Aβ) in a mouse model of the neurodegenerative disorder.

“Our study provides a molecular mechanism for Golgi fragmentation and its effects on APP [amyloid precursor protein] trafficking and processing in AD, suggesting Golgi as a potential drug target for AD treatment,” Yanzhuang Wang of the University of Michigan and colleagues said in a statement.

According to the authors’ poster abstract, the team proposes a pathway in which Aβ accumulation leads to the fragmentation of the Golgi apparatus via a kinase, cdk5. Blocking cdk5’s activity in a mouse model not only protected the integrity of Golgi, but also reduced Aβ. “A major...

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