Softness Indicates Metastatic Cells

An atomic force microscope with a microscale cantilever, and a petri dish of ovarian cancer cells.Georgia Institute of Technology, Rob FeltResearchers were able to use cell stiffness to differentiate between metastatic ovarian cancer cells and those that were less likely to spread and grow in new locations. Examining a cell line known to be highly metastatic and one that rarely metastasizes, the researchers measured the cells’ pliability by tapping them using a microscopic probe  and an atomic force microscope, and accurately predicted which cell line it came from, with cells of the metastatic line being consistently softer. The researchers say that the study, published earlier this month (October 4) in the journal PLOS ONE, could one day help doctors choose more or less aggressive treatment depending on whether the cancer is metastatic or not.

The finding makes sense, said author Todd Sulchek from Georgia Institute of Technology...