Stem cells emerge at night

Stem cells undergo circadian cycles in humans, emerging from the bone marrow into the bloodstream at higher concentrations at night than in the day, according to a report in __Cell Stem Cell__ linkurl:this week.;http://www.cellstemcell.com/ The study suggests that a simple change in hospital procedures could significantly increase stem cell yield for therapy. "We can take advantage of [the findings] if we coordinate our clinical practices" to harvest stem cells for cancer patients late in the

Edyta Zielinska
Oct 7, 2008
Stem cells undergo circadian cycles in humans, emerging from the bone marrow into the bloodstream at higher concentrations at night than in the day, according to a report in __Cell Stem Cell__ linkurl:this week.;http://www.cellstemcell.com/ The study suggests that a simple change in hospital procedures could significantly increase stem cell yield for therapy. "We can take advantage of [the findings] if we coordinate our clinical practices" to harvest stem cells for cancer patients late in the day, said author Paul Frenette, a clinical researcher at Mount Sinai School of Medicine. The work is an update on a paper published linkurl:online in February;http://www.nature.com/nature/journal/v452/n7186/abs/nature06685.html by the same group in __Nature.__ In that study, Frenette and his colleagues showed that haematopoietic stem cells (HSCs) leave their niche in mouse bone marrow and travel through the blood during the day -- the mouse's time of rest. A cytokine called CXCL12 expressed by stromal cells in...

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