“Your diet itself matters, not just whether you are gaining excess weight or developing gestational diabetes,” said coauthor Eric Zorrilla of the Scripps Research Institute, in a press release. This is a key finding that may have implications for managing human pregnancies, added collaborator Jen Frihauf, a PhD student at the University of California, San Diego, while working on the project. “Doctors often use weight gain as a hallmark of a healthy pregnancy,” Frihauf, now a postdoc at Scripps, said in the release. “But we realized there was something going on in utero that wasn’t detectable in the mother’s weight.”
The increased obesity risk appeared to be lifelong, with offspring more prone to obesity as infants, adolescents, and even adults. The offspring of rats on the Western diet also had altered metabolism, expending less energy while at rest, and elevated levels of insulin, leptin, and adiponectin—a hormone profile that the authors suggest may help detect obesity risk.
The team also found that offspring of obesity-prone rats that were fed the Western diet were less able to reproduce and more likely to have fewer offspring. “This wasn’t the focus of the study,” Zorilla said in the release. “But it supports the idea that a Western diet promotes infertility in mothers vulnerable to diet-induced obesity.”