The scent of fear

The nose may know more than we think: New research suggests a poorly-understood structure in the tip of the nose may regulate a vital mammalian alarm system. According to a paper published in linkurl:Science;http://www.sciencemag.org/ tomorrow (August 22), mice detect alarm pheromones -- signals evoking behavioral reactions such as fear and anxiety -- through a bundle of cells on the roof of the nasal cavity. This cell structure, first described by Hans Grueneberg in 1973 and called the Gruene

Megan Scudellari
Aug 20, 2008
The nose may know more than we think: New research suggests a poorly-understood structure in the tip of the nose may regulate a vital mammalian alarm system. According to a paper published in linkurl:Science;http://www.sciencemag.org/ tomorrow (August 22), mice detect alarm pheromones -- signals evoking behavioral reactions such as fear and anxiety -- through a bundle of cells on the roof of the nasal cavity. This cell structure, first described by Hans Grueneberg in 1973 and called the Grueneberg ganglion (GG), is an arrow-shaped mass of about 500 cells. The system is fully developed at birth in a mouse, said Marie-Christine Broillet, lead author on the paper, and it has been found in all mammals looked at so far. Yet its function had yet to be determined. In 2006, linkurl:researchers,;http://www.ncbi.nlm.nih.gov/pubmed/16307607?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum re-discovering the structure, found that the cells express multiple olfactory marker proteins and project axons to the olfactory bulb,...

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