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Top 7 biochemistry papers

#1 Complex I enzyme revealed The solved structure of a bacterial complex I enzyme -- first in line in the energy-producing respiratory chain -- reveals important mechanics of this ubiquitous protein. Specifically, the structure shows how it hustles electrons and protons across membranes. R.G. Efremov et al. "The architecture of respiratory complex I," Nature, 465(7297):441-5. 2010. linkurl:Eval;http://f1000biology.com/article/id/3375956 by Nathan Nelson, Tel Aviv University; Andrea Mattevi, U

Cristina Luiggi
#1 Complex I enzyme revealed The solved structure of a bacterial complex I enzyme -- first in line in the energy-producing respiratory chain -- reveals important mechanics of this ubiquitous protein. Specifically, the structure shows how it hustles electrons and protons across membranes. R.G. Efremov et al. "The architecture of respiratory complex I," Nature, 465(7297):441-5. 2010. linkurl:Eval;http://f1000biology.com/article/id/3375956 by Nathan Nelson, Tel Aviv University; Andrea Mattevi, University of Pavia; Terrence Frey, San Diego State University; Thomas Meier, Max Planck Institute of Biophysics.
E. coli cluster
Image:Eric Erbe via Wikimedia Commons
#2 Unusual aging in E. coli A novel microfluidics technique allowed researchers to study single E. coli cells as they birthed many clones throughout many generations -- proving their growth rate wasn't hampered by age, contradicting previous hypotheses and other aging models. P. Wang et al. "Robust Growth of Escherichia coli," Curr Biol, 20: 1099-1103. 2010. linkurl:Eval;http://f1000biology.com/article/id/3517956 by Roy...
#3 Why proteins have knotsA.L. Mallam et al. "Experimental detection of knotted conformations in denatured proteins," Natl Acad Sci, 107(18):8189-94. 2010. linkurl:Eval;http://f1000biology.com/article/id/3335966 by Werner Streicher and George Makhatadze, Rensselaer Polytechnic Institute; Aaron Burton and Niles Lehman, Portland State University.#4 Engineered: self-assembling membranesV. Percec et al. "Self-assembly of Janus dendrimers into uniform dendrimersomes and other complex architectures," Science, 328(5981):1009-14. 2010. linkurl:Eval;http://f1000biology.com/article/id/3436956 by Anthony Czarnik, University of Nevada; Donald Tomalia, Central Michigan University.#5 How proteins got their grooves backS. Stella et al. "The shape of the DNA minor groove directs binding by the DNA-bending protein Fis," Genes Dev, 24(8):814-26. 2010. linkurl:Eval;http://f1000biology.com/article/id/3018958 by Charles Dorman, Trinity College; Stephen CJ Parker and Tom Tullius; Boston University.#6 Predicting how proteins come togetherP.L. Kastritis and A.M. Bonvin. "Are scoring functions in protein-protein docking ready to predict interactomes? Clues from a novel binding affinity benchmark," J Proteome Res, 9(5):2216-25. 2010. linkurl:Eval;http://f1000biology.com/article/id/3437978 by Antonio Rosato, University of Florence; Gloria Fuentes and Chandra Verma, Bioinformatics Institute.#7 More clues to liver microRNA's role in diseaseD.D. Young et al. "Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma," J Am Chem Soc, 23: 7976-81. 2010. linkurl:Eval;http://f1000biology.com/article/id/3505956 by Subhash Sinha, The Scripps Research Institute; Nicholas Meanwell, Bristol Myers Squibb.



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