#1 A gene for autoimmunity Defective sialic acid acetylesterase (SIAE) -- an enzyme involved in the regulation of B lymphocyte signaling -- infers a greater risk of autoimmune disorders, such as rheumatoid arthritis and type I diabetes, and may contribute to the pathogenesis of such diseases. I. Surolia et al., "Functionally defective germline variants of sialic acid acetylesterase in autoimmunity," linkurl:__Nature,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20555325?dopt=Abstract&holding=f1000,f1000m,isrctn 466:243-7, 2010. linkurl:Eval by;http://bit.ly/sialicauto Mark Anderson, UCSF Diabetes Center; Anthony DeFranco, University of California, San Francisco; Takeshi Tsubata, Tokyo Medical University, Japan.
#2 Stem cells cater to infection When a host is infected by malaria, blood stem cells produce a new kind of progenitor that is better equipped to fight the disease, suggesting that some stem cells may be able to tailor their progeny to the disease the body is facing. N.N. Belyaev et al., "Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor...
Image: Aszakal via Wikimedia Commons
#3 Memory cells do more than rememberT.M. Strutt et al., "Memory CD4+ T cells induce innate responses independently of pathogen," linkurl:__Nat Med May__,;http://www.ncbi.nlm.nih.gov/sites/entrez/20436484?dopt=Abstract&holding=f1000,f1000m,isrctn 16:558-64, 2010. linkurl:Eval by;http://bit.ly/CD4Tmem Michael McChesney, UCSD; Damian Turner and Donna Farber, Columbia Univ. Medical Center; Linda Bradley Burnham Institute for Medical Research; Jay Kolls, Lousianna State Univ. Health Sciences Centre.#4 Gut adapts to new settlersS. Hapfelmeier, et al., "Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses," linkurl:__Science,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20576892?dopt=Abstract&holding=f1000,f1000m,isrctn 328:1705-9 2010. linkurl:Eval by;http://bit.ly/IgAdynamics Lora Hooper, Univ. of Texas Southwestern Medical Center; Denise A Kaminski and Troy Randall, Univ. of Rochester; Anthony DeFranco UCSF.#5 Clues to how dendritic cells moveK. Schumann et al., "Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells," linkurl:__Immunity,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20471289?dopt=Abstract&holding=f1000,f1000m,isrctn 32:703-13, 2010. linkurl:Eval by;http://bit.ly/chemokines Jens V Stein, Univ. Bern; Steve Ward Univ. of Bath; Philip Murphy National Institute of Allergy and Infectious Diseases; Xingfeng Bao and Minoru Fukuda Burnham Institute for Medical Research.#6 What makes a killerP. Li et al., "Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion," linkurl:__Science,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20538915?dopt=Abstract&holding=f1000,f1000m,isrctn 329:85-9, 2010. linkurl:Eval by;http://bit.ly/iTNKcells Eric Vivier Centre d'Immunologie de Marseille-Luminy; Deepta Bhattacharya Washington Univ. in St. Louis; Brittany Teague-Weber and Avinash Bhandoola Univ. of Pennsylvania.#7 Creating a new helper cellH. C. Chang "The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation," linkurl:__Nat Immunol,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20431622?dopt=Abstract&holding=f1000,f1000m,isrctn 11:527-34, 2010. linkurl:Eval by;http://bit.ly/PU1IL9 Dan Conrad Virginia Commonwealth University; Yrina Rochman and Warren Leonard National Institutes of Health; Amnon Altman Institute for Allergy and Immunology.
Interested in reading more?
Become a Member of
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!