Traditional Medicine for Leishmaniasis

A plant used in traditional Mayan remedies to cure the parasitic infection produces a potent compound.

kerry grens
Kerry Grens

Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at...

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Sep 14, 2015

WIKIPEDIA, PAULO HENRIQUE ORLANDI MAURAOThe roots of the plant Pentalinon andrieuxii have been used by Mayans for years to treat infections from the parasite Leishmania, and researchers know now why: a compound from the plant, newly synthesized in the lab, reduces parasite load in infected mice.

“Pentalinonsterol could represent the next generation of small-molecule-mediated immunotherapy for visceral leishmaniasis,” Elizabeth Sharlow, a pharmacologist at the University of Virginia who did not participate in the research, told Chemical & Engineering News.

The disease, caused by Leishmania protozoa, is typically transmitted by sand fly bites. Victims suffer fever and weight loss, and can die if untreated. Up to 40,000 people die each year from visceral leishmaniasis. Although there are treatments available, most are expensive, come with side effects, and can lead to drug resistance.

In seeking alternatives to the typical medications, Abhay Satoskar of Ohio State University and his colleagues...

In their latest report, published in ACS Infectious Diseases last month (August 15), the researchers wrapped their compound—called PEN—in liposomes and injected it into mice infected with L. donovani. “Liposomal PEN successfully rescued the impaired immune response of the L. donovani infected host by mediating a strong pro-inflammatory cytokine response,” Satoskar’s team wrote in its paper. “Additionally, it cleared parasite load in the liver, spleen, and bone marrow significantly better than controls, including the currently used clinical treatment, SSG.”

According to Chemical & Engineering News, the team is now designing an oral form of the medication and working to figure out its molecular mechanism.

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Traditional Medicine for Leishmaniasis

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