Menu

Understanding Antimalarial Drug Resistance

Researchers identify mutations associated with resistance to the frontline antimalarial drug artemisinin.

Jan 21, 2015
Tracy Vence

Photomicrograph of a blood smear that contains a macro- and microgametocyte of the Plasmodium falciparum parasiteWIKIMEDIA, CDCScanning the genomes of malaria parasites (Plasmodium falciparum) collected from 15 locations in Southeast Asia, scientists from the Wellcome Trust Sanger Institute and their colleagues have identified markers of resistance the frontline antimalarial drug artemisinin. Their work was published in Nature Genetics this week (January 19).

Through a human genome-wide association study, the U.K.-based team homed in on at least 20 mutations in a gene, kelch13, that are associated with slow parasite clearance rate after treatment with artemisinin-related compounds. Overall, the researchers found evidence to suggest that “the risk of new resistance-causing mutations emerging is determined by specific predisposing genetic factors in the underlying parasite population,” they wrote in their paper.

“Artemisinin is the best drug we have had for a very long time, and we want to continue this success story,” Olivo Miotto of the Mahidol-Oxford Tropical Research Unit in Thailand told BBC News. “And for that, its effectiveness has to be protected and sustained.”

April 2019

Will Car T Cells Smash Tumors?

New trials take the therapy beyond the blood

Marketplace

Sponsored Product Updates

Getting More Consistent Results by Knowing the Quality of Your Protein
Getting More Consistent Results by Knowing the Quality of Your Protein
Download this guide from NanoTemper to learn how to identify and evaluate the quality of your protein samples!
Myth Busting: The Best Way to Use Pure Water in the Lab
Myth Busting: The Best Way to Use Pure Water in the Lab
Download this white paper from ELGA LabWater to learn about the role of pure water in the laboratory and the advantages of in-house water purification!
Shimadzu's New Nexera UHPLC Series with AI and IoT Enhancements Sets Industry Standard for Intelligence, Efficiency and Design
Shimadzu's New Nexera UHPLC Series with AI and IoT Enhancements Sets Industry Standard for Intelligence, Efficiency and Design
Shimadzu Corporation announces the release of the Nexera Ultra High-Performance Liquid Chromatograph series, incorporating artificial intelligence as Analytical Intelligence, allowing systems to detect and resolve issues automatically. The Nexera series makes lab management simple by integrating IoT and device networking, enabling users to easily review instrument status, optimize resource allocation, and achieve higher throughput.
IDT lowers genomic barriers with powerful rhAmpSeq™ targeted sequencing system
IDT lowers genomic barriers with powerful rhAmpSeq™ targeted sequencing system
Increasing accuracy and reducing cost barriers, IDT’s innovative system delivers simple and cost-effective amplicon sequencing