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Unwinding DNA replication

Scientists have sorted out another piece of the DNA replication puzzle by showing what might happen to histones through the process of unwinding DNA. The linkurl:findings,;http://www.sciencemag.org published in today's (December 20) __Science__, identify a complex that can shuttle histones from parent to daughter strands of DNA as it replicates. As the replication fork moves along a strand of DNA, the linkurl:nucleosomes;http://www.the-scientist.com/article/display/23392 - the 4-histone pair c

kerry grens
Kerry Grens

Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at...

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Scientists have sorted out another piece of the DNA replication puzzle by showing what might happen to histones through the process of unwinding DNA. The linkurl:findings,;http://www.sciencemag.org published in today's (December 20) __Science__, identify a complex that can shuttle histones from parent to daughter strands of DNA as it replicates. As the replication fork moves along a strand of DNA, the linkurl:nucleosomes;http://www.the-scientist.com/article/display/23392 - the 4-histone pair complexes around which DNA spools - must come unhinged from DNA and reassemble on each of the daughter strands following replication. Scientists knew parent linkurl:histones,;http://www.the-scientist.com/article/display/23393 in addition to newly synthesized histones, end up on the daughter strands, but they didn't know how they got there. "This gives us a first handle to gain insights into the transfer mechanism underlying the transmission of parental histones," linkurl:Genevieve Almouzni;http://www.curie.fr/recherche/themes/detail_equipe.cfm/lang/_gb/id_equipe/4.htm at the Institut Curie in Paris and an author on the paper wrote in an Email to __The Scientist__....

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