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Week in Review, May 13–17

Reading pathogen epigenomes; a new stem cell; dealing with research misconduct; monkey fossils; exploratory mice grow new neurons; watching metamorphosis

May 17, 2013
Jef Akst

Bacterial epigenetics

FLICKR, NATHAN READINGDevelopers of a relatively new sequencer realized the machine’s ability to detect methylation and other modifications to bacterial DNA based on a slight time delay in the synthesis of the new strand. Now, researchers are applying the technique broadly to differentiate closely related bacterial strains, to better understand variation among pathogens, and to understand the role of DNA modification in disease virulence and spread by mapping the epigenomes of emerging pathogens.

“It’s like you’ve been in a closed room for a long time, and you open the window and look out,” Nobel Laureate Richard Roberts, chief scientific officer at New England Biolabs, told The Scientist. “And there’s a whole lot of stuff out there, and you don’t know where to look.”

A new kind of stem cell

CELL/TACHIBANA ET AL.First there were human embryonic stem cells (hESCs), but they came with a suite of ethical concerns—namely, the need to destroy human embryos to obtain them. Then there were induced pluripotent stem cells (iPSCs), derived from adult cells that had been de-differentiated into a ESC-like state. Now, researchers have presented a third option: hESCs produced via nuclear transfer (NT-hESCs), or the transfer of the nucleus from an adult cell into a human egg whose nucleus has been removed. The new technique may avoid the genetic and epigenetic abnormalities of iPSCs, and could have implications for treating mitochondrial disease, as the nuclear transfer results in a cell with a new set of mitochondria.

Preventing and rehabilitating misconduct: two opinions

WIKIMEDIA, SCHAAR HELMUTDespite more than 2 decades of widespread Responsible Conduct in Research (RCR) training programs for graduate students and postdocs, scientific misconduct is still on the rise. Clearly, it’s not working, argues James Hicks, a comparative and evolutionary physiologist at the University of California, Irvine. Meanwhile, Saint Louis University’s James DuBois and colleagues are looking to salvage the careers of those found guilty of misconduct. His REPAIR (Restoring Professionalism and Integrity in Research) program, which will host its second workshop this month, is “aimed at helping researchers make better professional decisions by anticipating consequences of actions and effectively managing stress, self-serving biases, compliance obligations, and challenges in the workplace.” But some researchers remain skeptical that the program will be successful, or that rule breakers deserve a second chance at all.

New fossils fill gap between monkey and ape

MAURICIO ANTONTwo new fossils uncovered in 25-million-year-old sediments provide clues regarding the split of apes, including humans, from Old World monkeys, such as baboons and macaques. That split is believed to have occurred between 25 and 30 million years ago, and previously the oldest fossils in these groups dated only to 20 million years ago. The new fossils—a molar belonging to the oldest known Old World monkey or cercopithecoid, and a jawbone and four teeth belonging to a new species—suggest that the split occurred when the climate was warming and the landscape was undergoing the beginnings of a drastic change that would form the Eastern African Rift from the formally flat Tanzanian plains. These changes could have resulted in new habitats and fueled primate diversification.

The environment’s role in neurogenesis

WIKIMEDIA, RAMAMore adventurous mice—that is, those that explored a complex environment more—grew more new neurons than their genetically identical counterparts, according to new research. The findings suggest that brain plasticity can be shaped by experience, which may influence the development of individuality.

 

 

Revealing metamorphosis

WIKIMEDIA, MICHAEL HANSELMANNHigh-resolution computer tomography (CT) scans reveal the details of the painted lady butterfly’s transformation from a caterpillar to a flying insect.

 

 

 

Other news in life science:

Suing Over a Nobel

The scientist who sued the Nobel committee is now suing Nobel winner Shinya Yamanaka.

Supreme Court Sides with Monsanto

The justices unanimously upheld Monsanto’s patent rights on Roundup Ready seeds.

Plants Communicate with Help of Fungi

Symbiotic fungi on the roots of bean plants can act as an underground signaling network, transmitting early warnings of impending aphid attacks.  

Epigenetics of Embryonic Stem Cells

Researchers track DNA modifications and gene expression in stem cells as they differentiate.

A New Way to Promote Science?

Members of Congress have suggested that the President should be able to pick a US Science Laureate.

Price Drop for Sequencing Slows

The cost of DNA sequencing has gotten more expensive for the first time since records have been kept.

February 2019

Big Storms Brewing

Can forests weather more major hurricanes?

Marketplace

Sponsored Product Updates

Bio-Rad Releases First FDA-Cleared Digital PCR System and Test for Monitoring Chronic Myeloid Leukemia Treatment Response
Bio-Rad Releases First FDA-Cleared Digital PCR System and Test for Monitoring Chronic Myeloid Leukemia Treatment Response
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a global leader of life science research and clinical diagnostic products, today announced that its QXDx AutoDG ddPCR System, which uses Bio-Rad’s Droplet Digital PCR technology, and the QXDx BCR-ABL %IS Kit are the industry’s first digital PCR products to receive U.S. Food and Drug Administration (FDA) clearance. Used together, Bio-Rad’s system and kit can precisely and reproducibly monitor molecular response to treatment in patients with chronic myeloid leukemia (CML).
Bio-Rad Showcases New Automation Features of its ZE5 Cell Analyzer at SLAS 2019
Bio-Rad Showcases New Automation Features of its ZE5 Cell Analyzer at SLAS 2019
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb) today showcases new automation features of its ZE5 Cell Analyzer during the Society for Laboratory Automation and Screening 2019 International Conference and Exhibition (SLAS) in Washington, D.C., February 2–6. These capabilities enable the ZE5 to be used for high-throughput flow cytometry in biomarker discovery and phenotypic screening.
Andrew Alliance and Sartorius Collaborate to Provide Software-Connected Pipettes for Life Science Research
Andrew Alliance and Sartorius Collaborate to Provide Software-Connected Pipettes for Life Science Research
Researchers to benefit from an innovative software-connected pipetting system, bringing improved reproducibility and traceability of experiments to life-science laboratories.
Corning Life Sciences to Feature 3D Cell Culture Technologies at SLAS 2019
Corning Life Sciences to Feature 3D Cell Culture Technologies at SLAS 2019
Corning Incorporated (NYSE: GLW) will showcase advanced 3D cell culture technologies and workflow solutions for spheroids, organoids, tissue models, and applications including ADME/toxicology at the Society for Laboratory Automation and Screening (SLAS) conference, Feb. 2-6 in Washington, D.C.