Zika and Birth Defects

A study provides stronger evidence for the causal link between Zika infection and microcephaly, and warns of a host of other birth defects associated with the virus.

Mar 8, 2016
Catherine Offord

A baby with microcephaly (left) compared to a baby with a typical-sized head (right)WIKIMEDIA, CDCMore than one-quarter of women taking part in a study of Zika infection during pregnancy had fetuses with potentially serious abnormalities, according to a report published last week (March 4) in the New England Journal of Medicine. The analysis compared fetuses in infected mothers to fetuses in non-infected mothers, thereby providing the control-like group that many previous studies have lacked.

The analysis is “what people have been waiting for,” Amesh Adalja of the University of Pittsburgh Medical Center, who was not involved in the work, told LiveScience, adding that the comparison of the two groups allowed stronger links to be drawn between Zika infection and microcephaly. “This is the closest we’ve gotten to [proving] causation. . . . For all intents and purposes, this justifies the concern raised early on.”

Of the 88 women enrolled in the study, 72 tested positive for Zika virus infection. While examination of the fetuses of all Zika-negative women found no defects, examinations of the fetuses in 42 Zika-infected women revealed abnormalities in 12, including central nervous system lesions (seven fetuses) and growth restriction with or without microcephaly (five fetuses). Two of the fetuses in Zika-infected women died at 36 and 38 weeks of gestation.

“We saw a very high percentage of abnormal fetal ultrasounds, and we saw a significant number of central nervous system findings, which is surprising to us,” study coauthor Karin Nielsen-Saines of the University of California, Los Angeles, told STAT News. “This alerts people that pregnancy in women affected with Zika are high-risk pregnancies.”

Catherine Spong of the National Institute of Child Health and Human Development, who was not involved with the study, told STAT that the results are important and concerning, but also noted that the sample sizes were small. “Stillbirth has many, many different causes, including maternal age [and] genetic factors,” she said.

The researchers suggested using the term “congenital Zika virus syndrome” to reflect the host of birth abnormalities now being linked to infection, Nielson-Saines told LiveScience. “Zika definitely causes the problems,” she said. “We think microcephaly is only the tip of the iceberg.”

September 2018

The Muscle Issue

The dynamic tissue reveals its secrets


Sponsored Product Updates

StemExpress LeukopakâNow Available in Frozen Format

StemExpress LeukopakâNow Available in Frozen Format

StemExpress, a Folsom, California based leading supplier of human biospecimens, announces the release of frozen Peripheral Blood Leukopaks. Leukopaks provide an enriched source of peripheral blood mononuclear cells (PBMCs) with low granulocyte and red blood cells that can be used in a variety of downstream cell-based applications.

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

Vector Laboratories, a leader in the development and manufacture of labeling and detection reagents for biomedical research, introduces VECTASHIELD® Vibrance™ – antifade mounting media that delivers significant improvements to the immunofluorescence workflow.

Enabling Genomics-Guided Precision Medicine

Enabling Genomics-Guided Precision Medicine

Download this eBook from Qiagen to learn more about the promise of precision medicine and how QCITM Interpret can help deliver better care with better knowledge.

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Download this white paper from Bertin Technologies to learn how to extract and analyze lipid samples from various models!