Menu

Aging-Related Diseases May Be a Negative Outcome of Human Evolution

Genetic adaptations for human brain development also make us vulnerable to Alzheimer’s disease, according to a new study.  

May 31, 2018
Sukanya Charuchandra

ISTOCK, THEDAFKISHWhile granting human species some advantages over our primate cousins, recent genomic adaptations appear to have come at a cost. Research published last week (May 23) in Cell Systems proposes that an evolutionary tradeoff, advantageous in early life, contributes to Alzheimer’s and possibly other aging-related diseases.

“I find the idea that genes that have been involved in the development of the human brain and in making the human brain different from the brains of great apes might also be genes that have the byproduct of raising the risk of Alzheimer’s is one of those ironic twists that seem to be pretty common in evolutionary biology,” says evolutionary biologist Stephen Stearns of Yale University who was not involved in this research.

 See “Genetic Adaptation to Cold Brought Migraines With It

In 1957, evolutionary biologist George Williams proposed a theory: adaptations that made species more fit in the early years of life likely made them more vulnerable to diseases in the post-reproductive years. However, there has been little research to support his theory.

Han Liang of the University of Texas MD Anderson Cancer Center led a team to test this theory. The researchers started by focusing on enhancers, pieces of DNA with the ability to boost the activities of certain genes, and therefore, the levels of resulting proteins. Previous research had identified enhancers as key to as key to human evolution after diverging from the last common ancestor with chimpanzees. Using FANTOM, an annotated database with information on expression levels of human-specific enhancers, Liang’s group compared human data with that of primates to find the fastest evolving enhancers. Comparisons with primates including chimpanzee, gorilla, orangutan, and macaque genomes revealed 93 such enhancers expressed within neurons and neuronal stem cells that had evolved rapidly in humans.

Liang’s group found that genes lying close to these enhancers, and therefore possibly under their control, were important for brain development. It is plausible that the enhancers were positively selected for during evolution because of their effects on these brain-related genes. However, they also found evidence of proximal associations between the enhancers and genes implicated in Alzheimer’s, Parkinson’s disease, type 2 diabetes, hypertension, and osteoporosis. According to Williams’s theory, these aging-related diseases would manifest later in life and would go unnoticed during the Darwinian selection process because of the advantage they bestowed in the early years. “Because this happened after reproduction, selection will not see those kinds of change,” says Liang.

“I think some of this evidence is correlative,” and the associations between the enhancers and aging-related diseases is not definitive evidence of cause-and-effect, says João Pedro de Magalhães, who studies aging at the University of Liverpool in the U.K., and was not involved in this research. However, he agrees that patterns are emerging from Liang’s data that imply that “something is indeed going on.”

In order to see if there is indeed a functional connection between the enhancers and aging-related diseases, Liang’s team used The Cancer Genome Atlas and GTEx, both large databases, to draw up gene maps highlighting all the genes coexpressed with each enhancer. The researchers targeted one such enhancer associated with brain development and also with genes known to be linked to brain diseases. When Liang’s group used CRISPR to delete the enhancer in human cell lines, protein abundance from its related genes fell. Importantly, some of these genes are usually suppressed by a gene called REST, which keeps Alzheimer’s at bay. However, in the presence of the functional enhancer, these genes are boosted. Thus, while this enhancer may be important for brain development, it seemingly opposes REST’s protective function against Alzheimer’s.

Randolph Nesse, who conducts research to understand the evolutionary origins of diseases at Arizona State University, describes the study as “a wonderful example about how evolutionary thinking and medicine is coming together with advances in genomics to open up a whole new area.”

H. Chen et al., “Fast-evolving human-specific neural enhancers are associated with aging-related diseases,” Cell Systems, doi:10.1016/j.cels.2018.04.002, 2018.

September 2018

The Muscle Issue

The dynamic tissue reveals its secrets

Marketplace

Sponsored Product Updates

Horizon Discovery introduces Myeloid DNA Reference Standard to support genetic testing of leukemia

Horizon Discovery introduces Myeloid DNA Reference Standard to support genetic testing of leukemia

Horizon Discovery Group plc, a global leader in gene editing and gene modulation technologies, today announced the launch of its Myeloid DNA Reference Standard. The first-to-market large cell-line derived myeloid cancer reference standard designed enables faster, more reliable and more cost-effective assay validation, to support the market in bringing routine testing into practice.

StemExpress LeukopakâNow Available in Frozen Format

StemExpress LeukopakâNow Available in Frozen Format

StemExpress, a Folsom, California based leading supplier of human biospecimens, announces the release of frozen Peripheral Blood Leukopaks. Leukopaks provide an enriched source of peripheral blood mononuclear cells (PBMCs) with low granulocyte and red blood cells that can be used in a variety of downstream cell-based applications.

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

Vector Laboratories, a leader in the development and manufacture of labeling and detection reagents for biomedical research, introduces VECTASHIELD® Vibrance™ – antifade mounting media that delivers significant improvements to the immunofluorescence workflow.

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Download this white paper from Bertin Technologies to learn how to extract and analyze lipid samples from various models!