Image of the Day: When Cells Stop Cleaning

By stifling autophagy in the motor neurons of a mouse model of amyotrophic lateral sclerosis (ALS), scientists stem later-stage disease progression.

Sep 12, 2017
The Scientist Staff

In the spinal interneurons of a mouse model of amyotrophic lateral sclerosis (ALS), protein aggregation (red and green) is clearly visible (left), while in mice engineered to quell autophagy (right), these aggregates are completely absent.TOM MANIATIS/COLUMBIA UNIVERSITY'S ZUCKERMAN INSTITUTESee N.D. Rudnick el al., “Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS,” PNASdoi:10.1073/pnas.1704294114, 2017.