Tools and Technology
GFT NMR Proves Its Structural Genomics Mettle
Aileen Constans | Dec 5, 2005
G-matrix Fourier transform (GFT) NMR, a technique developed several years ago for rapid collection of nuclear magnetic resonance data, has been used to determine the structures of eight proteins in less than a month.1 "People usually work for many months for one structure. And even a year is not unusual," says coauthor Thomas Szyperski of the University of Buffalo. [see related story, page 36]The work demonstrates for the first time that GFT NMR works on a "real world" scale, meaning a protein c
Agilent Launches ChIP-on-Chip
Aileen Constans | Dec 5, 2005
Chromatin immunoprecipitation (ChIP), or location analysis, is an antibody-based method for identifying the segments of DNA recognized by a particular transcription factor in a native chromatin environment.
Mapping MAPK Activation
Aileen Constans | Dec 5, 2005
are a hot topic these days.
Reconstructing Mammalian Cell Lineages
Aileen Constans | Dec 5, 2005
Adult nematode worms contain 959 somatic cells, and thanks to Nobel laureate John Sulston and colleagues, scientists know the lineage of every one of them.
Measuring Protein Concentrations in Live Cells
Sarah Rothman | Dec 5, 2005
data that's essential for mathematical modeling of biological pathways.
A cDNA Library, Literally
Lissa Harris | Nov 21, 2005
Geneticists subject to late-night bouts of inspiration generally have to write down their good ideas.
Crystallography for Everyone
Bennett Daviss | Nov 21, 2005
The Bruker AXS Smart Breeze X-ray crystallography system is an instrument that lives up to its name, says Bruker spokesperson Susan Byram.
Columns
JR Minkel | Nov 21, 2005
Two independent groups have demonstrated a new method for purifying proteins that may offer a simpler, cheaper alternative to large-scale column purification.
on Your Screen
Karen Heyman | Nov 21, 2005
Brian Fisher, curator of entomology at the California Academy of Sciences, has such enthusiasm for ants, he can make you feel guilty over spraying the little devils in your kitchen.
Affordable Gel Image Analysis
Aileen Constans | Nov 7, 2005
has just released the G:BOX, a modular image analysis system designed for a range of applications and budgets.