1. To stent or not? » A large randomized trial demonstrates that arterial stenting is as effective and safe as surgical intervention in treating narrowing (stenosis) of the carotid arteries, challenging previous work that showed stents were more risky.

T.G. Brott et al., N Engl J Med, 363:11-23, 2010

2. Drug helps, not hurts, lung disease » Patients with acute respiratory distress syndrome using a neuromuscular blocker are more likely than those on a placebo to survive 90 days, and show no increase in muscle weakness—a common concern among doctors.

L. Papazian et al, N Engl J Med, 363:1107-16, 2010.

3. Piezos for pain » A family of proteins, called Piezos, may be a component of mechanically activated ion channels, which make possible several senses, such as hearing, touch, and pain sensation.

B. Coste et al., Science, 330:55-60, 2010.


U.A. Ørom et al., Cell, 143:46-58, 2010.

5. Proficient pluripotency » Researchers created synthetic mRNAs, chemically modified to prevent innate-immune-system activation and more efficiently reprogram human cells to pluripotency—a significant advance in induced pluripotent stem cell technology.

L. Warren et al., Cell Stem Cell, 7:618-30, 2010.

6. Details of cell division » A complex of proteins crucial for the alignment and separation of chromosomes in dividing cells is directed to the centromeres by the phosphorylating actions of a specific kinase, revealing an important mechanism of cell division that has long escaped scientists.

F. Wang et al., Science, 330:231-35, 2010.

7. Better nuclei isolation » Researchers streamlined a method for tagging nuclei from specific cell types in plants, and purifying them to measure gene expression and chromatin modification across a variety of tissue types.

R.B. Deal, S. Henikoff, Dev Cell, 18:1030-40, 2010.

The F1000 Top 7 is a snapshot of the highest-ranked articles from a 30-day period on Faculty of 1000. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit

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