Top 7 From F1000

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1. To stent or not? » A large randomized trial demonstrates that arterial stenting is as effective and safe as surgical intervention in treating narrowing (stenosis) of the carotid arteries, challenging previous work that showed stents were more risky.

T.G. Brott et al., N Engl J Med, 363:11-23, 2010. Evaluated by G. Tang & J. Matsumura, Univ Wisconsin; M. Alberts, Northwestern Univ; M. Nishikawa & T. Milhorat, North Shore Univ Hosp; P. Pagel & C. J. Zablocki, VA Med Cen; P. Newfield, California Pac Med Cen; B. Norrving, Lund Univ Hosp; S. Kumar & S. Bangalore, Brigham & Women’s Hosp; Z. Anastasian & E.Heyer, Columbia Univ; N. Hertzer, The Cleveland Cln. Free F1000 Evaluation

2. Drug helps, not hurts, lung disease » Patients with acute respiratory distress syndrome using a neuromuscular blocker are more likely than those on a placebo...

L. Papazian et al, N Engl J Med, 363:1107-16, 2010. Evaluated by A. Benson & I. Douglas, Univ Colorado and Denver Health; M. Gropper, UCSF; R. Basner, Columbia Univ College of Physicians and Surgeons; J. Sellares & A. Torres, Hosp Cln de Barcelona; M. Gama de Abreu, Clinic Carl Gustav Carus; J. Neely & A. Vuylsteke, Papworth Hosp; G. Martin, Emory Univ; M. O’Connor, Univ Chicago; P. Fassbender & M. Eikermann, Mass Gen Hosp. Free F1000 Evaluation

3. Piezos for pain » A family of proteins, called Piezos, may be a component of mechanically activated ion channels, which make possible several senses, such as hearing, touch, and pain sensation.

B. Coste et al., Science, 330:55-60, 2010. Evaluated by M. Moran & D. Kimball, Hydra Biosciences; J. Garcia-Añoveros, Northwestern University; F. Viana, UMH Instituto de Neurociencias; P. Garrity, Brandeis Univ; B. Nilius, KU Leuven. Free F1000 Evaluation

4. New function for noncoding RNAs » Long noncoding RNAs, previously known to silence expression of certain genes, also play a role in gene activation.

U.A. Ørom et al., Cell, 143:46-58, 2010. Evaluated by L. Ringrose, Inst of Molecular Biotechnology GmbH; A. Clery, Dominik Theler, & F. Allain, ETH; J. Abrams, U of Texas Southwestern Med Cen at Dallas; H. Steinbeisser, Univ of Heidelberg; E. Lara-Pezzi & N. Rosenthal, EMBL. Free F1000 Evaluation

5. Proficient pluripotency » Researchers created synthetic mRNAs, chemically modified to prevent innate-immune-system activation and more efficiently reprogram human cells to pluripotency—a significant advance in induced pluripotent stem cell technology.

L. Warren et al., Cell Stem Cell, 7:618-30, 2010. Evaluated by R. Juliano, Univ North Carolina at Chapel Hill; B. Aranda-Orgilles & I. Aifantis, HHMI/NYU School of Med; K. Maass & G. Fishman, NYU Langone Med Cen; A. Kriegstein, UCSF. Free F1000 Evaluation

6. Details of cell division » A complex of proteins crucial for the alignment and separation of chromosomes in dividing cells is directed to the centromeres by the phosphorylating actions of a specific kinase, revealing an important mechanism of cell division that has long escaped scientists.

F. Wang et al., Science, 330:231-35, 2010. Evaluated by W. Earnshaw, Univ of Edinburgh; E. Avvedimento, Univ Federico II; S. Ems-McClung & C. Walczak, Indiana Univ; R. Medema, Univ. Med Cen Utrecht; K. Lee, NIH. Free F1000 Evaluation

7. Better nuclei isolation » Researchers streamlined a method for tagging nuclei from specific cell types in plants, and purifying them to measure gene expression and chromatin modification across a variety of tissue types.

R.B. Deal, S. Henikoff, Dev Cell, 18:1030-40, 2010. Evaluated by E. Dennis, CSIRO; E. Lam, Rutgers Univ; D. Chamovitz, Tel Aviv Univ; K. Schneitz, Technische Univ München; P. Kaufman, U Mass Med School. Free F1000 Evaluation

The F1000 Top 7 is a snapshot of the highest-ranked articles from a 30-day period on Faculty of 1000. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit

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