TOP 7 From F1000 Unlimited, Inc.

1. How cilia talk» New findings show how primary (nonmotile) cilia retain membrane proteins needed to send and receive extracellular signals—a barrier at the base of cilia made up of proteins called septins.

Q. Hu et al., Science, 329:436-39, 2010. Evaluated by A. Wittinghofer, Max-Planck Inst; J. Axelrod, Stanford; M. Labouesse, CNRS; S. Feng and W. Guo, U Penn; M Bettencourt-Dias, IGC; Y. Yamashita, UMich; H. Folsch, Northwestern; M. Wirschell and W. Sale, Emory; Y. Barral, ETH. Free F1000 Evaluation

2. Gut advantage» Salmonella is able to outcompete resident gut microbes by deriving energy from inflammation, the immune response that is supposed to combat the pathogen.

S.E. Winter et al., Nature, 467: 426-29. 2010. Evaluated D. Alpers, Washington Univ; A. Kurakin & R. Khosravi-Far, Beth Israel; M. Hensel, Erlangen; Y. Sun & M. O’Riordan, Univ Michigan; W.D Hardt, ETH...

3. Bacterial map» Researchers map the complete transcriptome of a major human pathogen. The novel sequencing approach will likely be useful for sequencing the transcriptomes of other important pathogens.

C.M. Sharma et al., Nature, 464:250-55, 2010. Evaluated by N. Ahmed, ILS; M. Hensel Erlangen; S.H. Sui & F. Brinkman, SFU; S. Vogt & T. Raivio, Univ Alberta; A. Danielli & V. Scarlato, Univ Bologna. Free F1000 Evaluation

4. Sensing proteins» Members of a family of proteins, called Piezos, have been identified as important players in mechanically activated ion channels, which are involved in several senses, such hearing, touch and pain sensation.

B. Coste et al., Science, 330:55-60, 2010. Evaluations by J. Garcia-Anoveros, Northwestern; F. Viana, UMHIN; P. Garrity, Brandeis Univ; B. Nilius, KU Leuven. Free F1000 Evaluation

5. Nickel allergies» Allergy to nickel-plated jewelry is initiated because Toll-like receptor 4 (TLR4) binds to and recognizes the metal in much the same way that it recognizes lipopolysaccharides, a component of the bacterial cell wall.

M. Schmidt et al., Nat Immunol, 11:814-19, 2010. Evaluated by H. Goodridge & D. Underhill, Cedars-Siani; M. Rothenberg, Cincinnati Children’s HMC; C. R. Sousa, Cancer Research UK; M. Maroney, U Mass. Free F1000 Evaluation

6. Gut peace treaty» Dendritic cells of the gut keep beta-catenin signaling constantly turned on to subdue inflammatory responses against commensal bacteria and food antigens, offering a potential therapeutic target for autoimmune diseases.

S. Manicassamy et al., Science, 329:849-53, 2010. Evaluation by C. Fagundes & M. Teixeira, UFMG; K. Takeda, Osaka Univ; J. Berzofsky, NCI; B. Rouse, Univ Tennessee; Torben Lund, UCL. Free F1000 Evaluation

7. Epigenetics in mind» Genomic imprinting is much more widespread in the brain than scientists have believed, according to a new genome-wide study in mice. Surprisingly, more than 1,300 genes in the mouse brain exhibit “parent-of-origin” epigenetic effects.

C. Gregg, et al., Science, 329:643-48, 2010. Evaluations by R. Sapolsky, Stanford; M.E. Carter & L. Lecea, Stanford; J. Messing, Rutgers; Y. Ikeuchi & A. Bonni, Harvard Med; D. Sweatt, Univ Alabama. Free F1000 Evaluation

The F1000 Top 7 is a snapshot of the highest-ranked articles from a 30-day period on Faculty of 1000 Biology. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit

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