Top 7 From F1000

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1. Gene + virus + injury = disease? » New details on how the interaction of genes and environment results in disease: A bowel disease resembling Crohn’s needs a specific mutation, virus, and injury to develop in mice.

K. Cadwell et al., Cell, 141:1135–45, 2010. Eval by A. Baum and A. Farcia-Sastre, Mt Sinai; C. Karp, Cincinnati Children’s; C. Weber and J. Turner, Univ of Chicago.

2. New model for autophagy » C. elegans may be a powerful new animal model to study autophagy in higher eukaryotes: Researchers identified and defined the function of four autophagy genes in the species.

Y. Tian et al., Cell, 141:1042–55, 2010. Eval by C. McPhee and E. Baehrecke, UMass Med Sch; M. Markaki and N. Tavernarakis, Found Res and Tech, Greece.

3. Infection triggers new protection » A novel finding changes the...

N. N. Belyaev et al., Nat Immunol, 11:477–85, 2010. Eval by J. Deshane and D. Chaplin, Univ Ala; C. Engwerda, QIMR.

4. PRIMEtime tagging » There’s a new, smaller alternative to green fluorescent protein: PRIME (PRobe Incorporation Mediated by Enzymes) is a single-step, 10-minute technique using a fluorophore ligase derived from E. coli to tag and image proteins in living cells, without affecting its location or function.

C. Uttamapinant et al., Proc Natl Acad Sci, 107:10914–19, 2010. Eval by M. Golynskiy and B. Seelig, Univ Minn; J. Grunewald, GNF, Calif; J. Scheinost and R. Oliveira, Univ Oxford; K. Runager and D. Rubenstein, UNC-Chapel Hill; B. Oakley, OSU.

5. Gut adapts to new settlers » When new varieties of commensal bacteria enter the gut, the immune system quickly switches gears, first attacking then accepting the new settlers, suggesting that gut immunity differs from other arms of the immune system, which continue aggression if a new pathogen persists.

S. Hapfelmeier et al., Science, 328:1705–9, 2010. Eval by L. Hooper, UT SW Med Center; D. A. Kaminski and T. Randall, Univ Rochester; A. DeFranco, UCSF.

6. A double-edged gene » Protein variants that confer resistance to African sleeping sickness may also make African Americans more susceptible to kidney disease. Two independent variants of a gene linked to kidney disease, common in African chromosomes, both lyse a specific strain of trypanosomes.

G. Genovese et al., Science, Epub 2010 July 15. Eval by W. Gibson, Univ Bristol; M. Breyer, Lilly, Indianapolis.

7. When good guys go bad » Researchers have identified a species of commensal bacteria in the gut able to trigger autoimmune arthritis.

H. J. Wu et al., Immunity, 32:815–27, 2010. Eval by C. Fagundes and M. Teixeira, Univ Federal De Minas Gerais; A. Ho and S. Gaffen, Univ Pittsburgh; E.C. Snow, Univ KY; R. M. Hinman and J. Cambier, Nat Jewish Med Res Center, CO.

The F1000 Top 7 is a snapshot of the highest-ranked articles from a 30-day period on Faculty of 1000 Biology. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit Find Top 7s by searching for the IDs provided.

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