linkurl:1. Diabetes drug details unveiled; Researchers uncovered the details of how a common diabetes treatment works -- by blocking the phosphorylation of a master regulator of fat development, thereby suppressing the activation of genes that promote insulin insensitivity -- providing clues that may help reduce side effects, such as weight gain. J.H. Choi et al., "Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5," linkurl:__Nature,__; 466:451-6, 2010. Evaluated by Perry Bickel, Univ of Texas; Paul Webb, Methodist Hosp Res Inst; Michael Andresen, Oregon Health and Science Univ; Lawrence Hamann, Novartis. linkurl: Free F1000 Evaluation;
__Salmonella typhimurium__ culture
Image: NIAID, NIH/ linkurl:Wikimedia Commons;
linkurl:2. Combo causes Crohn's; The toxic chemicals produced by a combination of factors -- including a chronic viral infection, a mutation in a disease susceptibility gene, and possibly also commensal bacteria -- drive this intestinal autoimmune disease in a mouse model, giving researchers new leads for discovering the...
K Cadwell, et al., "Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine," linkurl:__Cell,__; 141:1135-45, 2010. Evaluated by Daniel S Mansur and Mauro Teixeira, Univ Federal De Minas Gerais, Brazil; Christopher Weber and Jerrold Turner, Univ of Chicago; Christopher Karp, Cincinnati Children's Hosp Res Foundation; Alina Baum and Adolfo Garcia-Sastre, Mount Sinai School of Med. linkurl: Free F1000 Evaluation; linkurl:3. Nickel allergy explained; M. Schmidt et al., "Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel," linkurl:__Nat Immunol,__; 11:814-9, 2010. Evaluated by Marc Rothenberg, Cincinnati Children's Hosp Med Center; Caetano Reis e Sousa, Cancer Research UK; Michael Maroney, Univ of Massachusetts. linkurl: Free F1000 Evaluation; linkurl:4. A test for TB?; M.P. Berry, et al., "An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis," linkurl:__Nature,__; 466:973-7, 2010. Evaluated by Rino Rappuoli, Chiron Corporation, Italy; Jeremy McAleer and Jay Kolls, Lousianna State Univ Health Sciences Centre; Andrea Cooper, Trudeau Institute. linkurl: Free F1000 Evaluation; linkurl:5. Making peace with gut flora; S. Manicassamy et al., "Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine," linkurl:__Science,__; 329:849-53, 2010. Evaluation by Jay Berzofsky, Center for Cancer Research, NCI; Barry Rouse, Univ of Tennessee; Torben Lund, University College London. linkurl: Free F1000 Evaluation; linkurl:6. New tool for HIV vaccine; X. Wu et al., "Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1," linkurl:__Science,__; 329:856-61, 2010. Evaluation by Alan Landay, Rush Univ Med Center; Jeffrey Bergelson, University of Pennsylvania; Rino Rappuoli, Chiron Corporation. linkurl: Free F1000 Evaluation; linkurl:7. Useless antibodies promote infection; C.A. MacLennan et al., "Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults," linkurl:__Science,__; 328:508-12, 2010. Evaluation by Marie-Eve Blais and Sarah Rowland-Jones, John Radcliffe Hosp, UK; Ken Wilson, Duke University; David Payne, GlaxoSmithKline. linkurl: Free F1000 Evaluation;

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