#1 T cell debate solved Mature T cells in the thymus are attracted to a molecule expressed by cells covering blood vessels, resolving a long standing puzzle of how cells escape into the body to fight infections. linkurl:(See our news story here.);http://www.the-scientist.com/blog/display/57375/ M.A. Zachariah, J.G. Cyster, "Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction," linkurl:__Science,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20413455?dopt=Abstract&holding=f1000,f1000m,isrctn 328:1129-35, 2010. linkurl:Eval by;http://f1000biology.com/article/zcq4z3zpg4t2nfr/id/3790964 Serge van de Pavert and Reina Mebius, VU Univ Med Center, Netherlands; Ivan Dzhagalov and Ellen Robey, University of California, Berkeley.
#2 No gray area for T cell activation Looking at the molecular dynamics of single T cells rather than the traditional technique of averaging the dynamics of multiple lysed cells, researchers saw that the T cell is activated in an "all or nothing" manner, challenging the conventional wisdom and demonstrating the power of the technique. S. Tay et al.,...
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bacteria. Image: Wikimedia Commons/Etxrge |
#3 Stem cells cater to infectionN.N. Belyaev et al., "Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria," linkurl:__Nat Immunol,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20431620?dopt=Abstract&holding=f1000,f1000m,isrctn 11:477-85, 2010. linkurl:Eval by;http://f1000biology.com/article/lc2kd4l341mwddy/id/3857961 Jessy Deshane and David Chaplin, Univ of Alabama at Birmingham; Christian Engwerda Queensland Institute of Medical Research.#4 When good guys go badH.J. Wu et al., "Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells," linkurl:__Immunity,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20620945?dopt=Abstract&holding=f1000,f1000m,isrctn 32:815-27, 2010. linkurl:Eval by;http://f1000biology.com/article/7lj9yq044xkzl15/id/3882960 Caio Fagundes and Mauro Teixeira, Universidade Federal De Minas Gerais, Brazil; Allen Ho and Sarah Gaffen, University of Pittsburgh; E Charles Snow, University of Kentucky Medical Center; Rochelle Marie Hinman and John Cambier, National Jewish Medical and Research.#5 New gut ecosystem model?K.S. Hayes et al., "Exploitation of the intestinal microflora by the parasitic nematode Trichuris muris," linkurl:__Science,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20538949?dopt=Abstract&holding=f1000,f1000m,isrctn 328:1391-94, 2010. linkurl:Eval by;http://f1000biology.com/article/wjgrzbj2nz0jbpr/id/3941956 Paul J Brindley, George Washington University; Adam Savage and Richard Locksley, University of California, San Francisco; Thomas Nutman, National Institutes of Health.#6 Suppressing TB-fightersS. Shafiani et al., "Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis," linkurl:__J Exp Med,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20547826?dopt=Abstract&holding=f1000,f1000m,isrctn 207:1409-20, 2010. linkurl:Eval by;http://f1000biology.com/article/1zks69bp1w1t21m/id/3869956 Stanley Perlman, University of Iowa; Andrea Cooper, Trudeau Institute; Nandini Krishnamoorthy and Anuradha Ray, University of Pittsburgh.#7 Enzyme's role diminishesK. Nika et al., "Constitutively active Lck kinase in T cells drives antigen receptor signal transduction," linkurl:__Immunity,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20541955?dopt=Abstract&holding=f1000,f1000m,isrctn 32:766-77, 2010. linkurl:Eval by;http://f1000biology.com/article/9794qz2kr1tg0d7/id/4154956 E Charles Snow, University of Kentucky Medical Center; Larry Kane, University of Pittsburgh.
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