linkurl:1. SWEET proteins found; A new class of proteins, dubbed SWEETs, function as glucose transporters, shuttling sugar molecules out of plant, worm and human cells. In some plants, SWEET proteins are co-opted by bacterial pathogens to deliver nutrition to the invaders.L.Q. Chen et al., linkurl:"Sugar transporters for intercellular exchange and nutrition of pathogens,"; __Nature__, 468:527-32, 2010. Evaluations by Julian Schroeder, UCSD; Akiko Sugio and Saskia Hogenhout, The John Innes Centre, UK; John Patrick, Univ Newcastle, Australia; David Alpers, Wash U Sch of Med; Bruno Stieger, Univ Hosp Zurich; Tapio Palva, Univ Helsinki; H Ekkehard Neuhaus, Univ Kaiserslautern, Germany. linkurl:Free F1000 Evaluation; linkurl:2. Identifying the unknown;
Image: flickr, AJC1
Researchers present a novel method for identifying antibody biomarkers for diseases without known antigens. The technique, which involves searching for antibodies that bind to various synthetic molecules, may prove useful for identifying diagnostic markers in a wide variety of...
M.M. Reddy, et al., linkurl:"Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening,"; Cell, 144:132-42, 2011. Evaluated by Angela Vincent, Univ of Oxford, UK; Robert Powers, Univ of Nebraska; Soumitra Ghosh and Kavita Shah, Purdue Univ; Ivan Gerling, Univ Tennessee Health Sci Cen; David Holtzman, Wash Univ School of Med. linkurl:Free F1000 Evaluation; linkurl:3. Motor protein visualized; A.P. Carter et al., linkurl:"Crystal structure of the dynein motor domain,"; __Science__, 331:1159-65, 2011. Evaluated by Terrence Frey, San Diego State Univ.; Linda Amos, MRC Lab of Molecular Bio, UK; Giampietro Schiavo, Imperial Cancer Research Fund, UK; Sharyn Endow, Duke Univ. Medical Center; Peter Stathopulos and Mitsuhiko Ikura, Ontario Cancer Inst, Canada. linkurl:Free F1000 Evaluation; linkurl:4. Inflammatory scissors; G. Xu et al., linkurl:"Crystal structure of inhibitor of kappaB kinase beta,"; __Nature__, doi:10.1038/nature09853, 2011. Evaluated by Andrew Beenken and Moosa Mohammadi, NYU Langonne Medical Center; John Kyriakis, Tufts Medical Center. linkurl:Free F1000 Evaluation; linkurl:5. Artificial proteins to the rescue;
Image: flickr, CdePaz
M.A. Fisher et al., linkurl:"De novo designed proteins from a library of artificial sequences function in Escherichia coli and enable cell growth,"; __PLoS One__, 6(1):e15364, 2011. Evaluated by Etienne Joly, CNRS, France; Donald Doyle, Georgia Inst of Technology; Ulrich Muller. linkurl:Free F1000 Evaluation; linkurl:6. Two-timing transporters; J.F. Dishinger et al., linkurl:"Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP,"; __Nat Cell Biol__, 12:703-10, 2011. Evaluated by Yuh Min Chook, Univ of Texas; Monica Bettencourt-Dias, Inst Gulbenkian de Ciencia, Portugal; Michael Rape, Berkeley Univ; Jonathan Bird and Thomas Friedman, NIDCD NIH. linkurl:Free F1000 Evaluation; linkurl:7. Epigenome interrupted;
Image: flickr, AJC1
P. Sarkies et al., linkurl:"Epigenetic instability due to defective replication of structured DNA,"; __Mol Cell__, 40:703-13, 2010. Evaluated by Matthew Bochman and Virginia Zakian, Princeton Univ; Alan Lehmann, Univ of Sussex, UK; Antony Carr, Univ of Sussex, UK. linkurl:Free F1000 Evaluation;

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