linkurl:1. Eukaryotic ribosome unveiled;
Atomic structure of the 50S large subunit of the ribosome
Image: Wikimedia commons, Vossman
The long-sought crystal structure of the translational machinery in yeast reveals unique interactions within and between the ribosome's two subunits and promises to lead to a better understanding of protein synthesis in eukaryotes. A. Ben-Shem et al., "Crystal structure of the eukaryotic ribosome,"linkurl: Science,; 330:1203-09, 2010. Evaluated by Daniel Gallie, UC Riverside; Margaret Elvekrog, Daniel MacDougall and Ruben Gonzalez, Columbia Univ; Robert Batey, Univ. of Colorado at Boulder; Dmitri Ermolenko and George Makhatadze, Rensselaer Polytechnic Institute. linkurl:Free F1000 Evaluation; linkurl:2. Detailing protein dynamics; the classic approaches of ambient temperature X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, researchers detail the conversion between different states of an enzyme, and how those dynamics affect catalytic activity. J.S. Fraser, et al., "Hidden alternative structures of proline isomerase essential for catalysis,"...
3. The genome shuffleP.J. Stephens, et al., "Massive genomic rearrangement acquired in a single catastrophic event during cancer development," linkurl:Cell,; 144:27-40, 2011. Evaluated by Jordi Camps and Thomas Ried, NCI; Yamini Dalal, NCI; Giovanni Neri, Univ Cattolica S Cuore; Robert Booth, Virobay Inc; Yan Xu and Makoto Komiyama, Univ Tokyo. linkurl:Free F1000 Evaluation; 4. Taming inflammationE. Nicodeme, et al., "Suppression of inflammation by a synthetic histone mimic," linkurl:Nature,; 468:1119-23, 2010. Evaluated by Lionel Ivashkiv, Hosp for Special Surgery; Marc Rothenberg, Cincinnati Children's Hosp Med Cen; Xiaodong Cheng, Emory Univ School of Med. linkurl:Free F1000 Evaluation; 5. Elusive intermediate #1 capturedJ. Rittle and M.T. Green, "Cytochrome P450 compound I: capture, characterization, and C-H bond activation kinetics," linkurl:Science,; 330:933-37, 2010. Evaluated by Elizabeth Gillam, Univ Queensland; Ivo Feussner, Georg August Univ. G?ttingen, Germany; Russ Hille, UC Riverside; Kap-Sun Yeung and Nicholas Meanwell, Bristol Myers Squibb. linkurl:Free F1000 Evaluation; 6. ATP machine close-upL.K. Lee, et al., "The structure of the peripheral stalk of Thermus thermophilus H+-ATPase/synthase," linkurl:Nat Struct Mol Biol,; 17:373-78, 2010. Evaluated by Ingo Grotjohann and Petra Fromme, Arizona State University; E Neil G Marsh, University of Michigan; Thomas Meier, Max Planck Institute of Biophysics; Michael Galperin, NIH; Stephan Wilkens, SUNY Upstate Medical University. linkurl:Free F1000 Evaluation; 7. Identifying the unknownM.M. Reddy, et al., "Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening," linkurl:Cell,; 144:132-42, 2011. Evaluated by Soumitra Ghosh and Kavita Shah, Purdue Univ; Ivan Gerling, Univ Tennessee Health Sci Cen; David Holtzman, Wash Univ School of Med. linkurl:Free F1000 Evaluation;

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